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CS-W001157 4
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(Tetrahydrofuran-3-yl)methanamine

  • CAS No. 165253-31-6

  • Cat. No. CS-W004787
  • Purity≥98%
  • MDL No.MFCD08234925

*For research and further manufacturing use only, not for direct human use.

(Tetrahydrofuran-3-yl)methanamine|CS-W004787

Structure of 165253-31-6

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General Information

  • CAS No. 165253-31-6
  • Cat. No. CS-W004787
  • Purity ≥98%
  • MDL No. MFCD08234925
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₁₁NO
  • Molecular Weight 101.15
  • Synonym(s) 1-(tetrahydrofuran-3-yl)methanamine
  • SMILES NCC1CCOC1

Description

(Tetrahydrofuran-3-yl)methanamine is a bench-stable, moisture-tolerant amine featuring a tetrahydrofuran ring that enhances solubility and stereochemical control. This scaffold integrates readily into synthetic routes requiring polar, flexible linkers. It serves as a key building block for bioactive molecule design and functionalized polymers.

Application

(Tetrahydrofuran-3-yl)methanamine serves as a versatile chiral building block in medicinal chemistry, enabling the synthesis of bioactive heterocycles and peptide mimetics. Its tetrahydrofuran ring imparts favorable conformational rigidity and metabolic stability, while the primary amine facilitates straightforward derivatization via acylation, alkylation, or reductive amination. The compound exhibits excellent bench stability and compatibility with standard purification techniques, making it well-suited for iterative synthetic campaigns and API precursor development.

Safety Information

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GHS Pictogram :
GHS No : GHS02,GHS05,GHS07
Signal Word : Danger
UN#: 2924
Class : 3
Packing Group : Ⅲ
Hazard Statements : H226-H315-H318-H335
Precautionary Statements : P210-P233-P240-P280

Quality Control

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Computational Chemistry Data

  • TPSA   35.25
  • LogP   -0.0184
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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