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CS-W001157 4
Total: USD 88.00

(1-Methyl-1H-pyrazol-4-yl)methanamine

  • CAS No. 400877-05-6

  • Cat. No. CS-0045012
  • Purity≥97%
  • MDL No.MFCD02090924

*For research and further manufacturing use only, not for direct human use.

(1-Methyl-1H-pyrazol-4-yl)methanamine|CS-0045012

Structure of 400877-05-6

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General Information

  • CAS No. 400877-05-6
  • Cat. No. CS-0045012
  • Purity ≥97%
  • MDL No. MFCD02090924
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₉N₃
  • Molecular Weight 111.15
  • Synonym(s) C-(1-METHYL-1H-PYRAZOL-4-YL)-METHYLAMINE
  • SMILES NCC1=CN(C)N=C1

Description

This pyrazole-based amine integrates a methylated pyrazole ring with a primary amine handle, offering enhanced solubility and stability in polar solvents. The functionalized scaffold enables direct coupling in peptide and heterocyclic synthesis, serving as a key building block for bioactive molecule development.

Application

(1-Methyl-1H-pyrazol-4-yl)methanamine serves as a versatile building block in medicinal chemistry, enabling the synthesis of pyrazole-based scaffolds prevalent in kinase inhibitors and CNS-targeted therapeutics. The primary amine functionality facilitates straightforward derivatization via amidation, alkylation, and reductive amination, while the methylated pyrazole ring ensures good metabolic stability and favorable solubility profiles. Its bench-stable, crystalline form simplifies handling and purification, making it well-suited for high-throughput screening and process-scale synthesis.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   43.84
  • LogP   -0.1212
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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