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Oxolan-3-ylmethanamine hydrochloride

  • CAS No. 184950-35-4

  • Cat. No. CS-0048762
  • Purity≥97%
  • MDL No.MFCD08448154

*For research and further manufacturing use only, not for direct human use.

Oxolan-3-ylmethanamine hydrochloride|CS-0048762

Structure of 184950-35-4

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General Information

  • CAS No. 184950-35-4
  • Cat. No. CS-0048762
  • Purity ≥97%
  • MDL No. MFCD08448154
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₁₂ClNO
  • Molecular Weight 137.61
  • Synonym(s) (Tetrahydrofuran-3-yl)methanamine hydrochloride
  • SMILES NCC1CCOC1.Cl

Description

Oxolan-3-ylmethanamine hydrochloride features a pyrrolidine ring fused to an oxygen atom, delivering a rigid, electron-rich scaffold ideal for medicinal chemistry. The pendant primary amine, protonated as the hydrochloride salt, enhances solubility and facilitates downstream derivatization. This bench-stable compound serves as a key building block in targeted synthesis.

Application

Oxolan-3-ylmethanamine hydrochloride serves as a versatile building block for the synthesis of bioactive heterocycles and pharmaceutical intermediates. The amine functionality enables straightforward derivatization via reductive amination, amidation, or alkylation, while the oxolane ring provides structural rigidity and metabolic stability. Its crystalline hydrochloride salt form enhances bench stability and simplifies purification, making it well-suited for scalable medicinal chemistry campaigns.

Synthesis

  • Route1

    References

    • SIGNAL PHARMACEUTICALS, LLC Patent: WO2008/51493 A2, 2008 ; Location in patent: Page/Page column 173 ;
  • Route2
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      165253-28-1
    • ~%
    • In-stock
      Oxolan-3-ylmethanamine hydrochloride|CS-0048762
      184950-35-4

    References

    • WO2012/133861 A1, ; Page/Page column 208-209 ;
  • Route3

    References

    • WO2012/133861 A1, ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05,GHS07
Signal Word : Danger
UN#: 1759
Class : 8
Packing Group : Ⅲ
Hazard Statements : H315-H318-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   35.25
  • LogP   0.4034
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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