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CS-W001157 4
Total: USD 88.00

Benzophenone, 4,4'-difluoro-

  • CAS No. 345-92-6

  • Cat. No. CS-0015469
  • Purity≥98%
  • MDL No.MFCD00000353

*For research and further manufacturing use only, not for direct human use.

Benzophenone, 4,4'-difluoro-|CS-0015469

Structure of 345-92-6

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General Information

  • CAS No. 345-92-6
  • Cat. No. CS-0015469
  • Purity ≥98%
  • MDL No. MFCD00000353
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₃H₈F₂O
  • Molecular Weight 218.20
  • Synonym(s) 4,4’-difluoro-benzophenon
  • SMILES O=C(C1=CC=C(F)C=C1)C2=CC=C(F)C=C2

Description

4,4-Difluorobenzophenone has been used in the study of thermal stability, water uptake and proton conductivity of carboxylated, carboxylated/sulfonated, and crosslinked membranes.

Application

4,4'-Difluorobenzophenone serves as a valuable building block in the synthesis of pharmaceutical intermediates and functional materials. Its dual fluorine substituents enhance metabolic stability and modulate electronic properties, while the ketone functionality enables diverse transformations including nucleophilic additions, Grignard reactions, and transition-metal-catalyzed couplings. The compound exhibits excellent bench stability and facilitates straightforward purification, making it well-suited for iterative synthetic sequences in medicinal chemistry and materials science applications.

Synthesis

  • Route1
    • p-Fluorobenzenecarboxaldehyde Atorvastatin calcium|CS-0214005
      459-57-4
    • ~49%
    • In-stock
      Benzophenone, 4,4'-difluoro-|CS-0015469
      345-92-6

    References

    • Yang, Luo; Zeng, Tieqiang; Shuai, Qi; Guo, Xiangyu; Li, Chao-Jun Chemical Communications, 2011 , vol. 47, # 7 p. 2161 - 2163
  • Route2

    References

    • Mitsui Toatsu Chemicals, Inc. Patent: US4453009 A1, 1984 ;
  • Route3
    • null|null
      79-37-8
    • null|null
      437-29-6
    • ~84%
    • In-stock
      Benzophenone, 4,4'-difluoro-|CS-0015469
      345-92-6

    References

    • Rao, Maddali L. N.; Venkatesh, Varadhachari; Dasgupta, Priyabrata Tetrahedron Letters, 2010 , vol. 51, # 38 p. 4975 - 4980

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07,GHS09
Signal Word : Warning
UN#: 3077
Class : 9
Packing Group : Ⅲ
Hazard Statements : H302-H315-H319-H335-H411
Precautionary Statements : P261-P264-P270-P271-P273-P280-P302+P352-P304+P340-P330-P362+P364-P391-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   17.07
  • LogP   3.1958
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   2

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