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CS-W001157 4
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Bis(3-fluorophenyl)methanone

  • CAS No. 345-70-0

  • Cat. No. CS-W014800
  • Purity≥98%
  • MDL No.MFCD00000337

*For research and further manufacturing use only, not for direct human use.

Bis(3-fluorophenyl)methanone|CS-W014800

Structure of 345-70-0

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General Information

  • CAS No. 345-70-0
  • Cat. No. CS-W014800
  • Purity ≥98%
  • MDL No. MFCD00000337
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₃H₈F₂O
  • Molecular Weight 218.20
  • Synonym(s) 3,3'-Difluorobenzophenone
  • SMILES O=C(C1=CC=CC(F)=C1)C2=CC=CC(F)=C2

Description

3,3-Difluorobenzophenone may be used in chemical synthesis.

Application

Bis(3-fluorophenyl)methanone serves as a robust aryl ketone building block for the construction of biaryl and heterocyclic scaffolds. Its fluorinated aryl groups enhance metabolic stability and modulate electronic properties, while the central carbonyl enables facile nucleophilic addition and condensation reactions. The compound exhibits excellent bench stability and compatibility with standard purification techniques, facilitating its use in medicinal chemistry campaigns and process-scale synthesis.

Synthesis

  • Route1

    References

    • Nolte, Christoph; Mayr, Herbert European Journal of Organic Chemistry, 2010 , # 8 p. 1435 - 1439
  • Route2

    References

    • Journal of Organic Chemistry, , vol. 70, # 26 p. 10709 - 10716
  • Route3
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      107337-71-3
    • ~%
    • In-stock
      Bis(3-fluorophenyl)methanone|CS-W014800
      345-70-0

    References

    • Journal of Organic Chemistry, , vol. 70, # 26 p. 10709 - 10716

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   17.07
  • LogP   3.1958
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   2

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