4-Chloro-7-fluoroquinazoline

Name: 4-Chloro-7-fluoroquinazoline
Brand: ChemScene
Availability: InStock
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CAS No. 16499-62-0
Cat. No. CS-D0286
Purity≥96%
MDL No.MFCD08236729

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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General Information

CAS No. 16499-62-0
Cat. No. CS-D0286
Purity ≥96%
MDL No. MFCD08236729
Storage -20°C, sealed storage, away from moisture
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₈H₄ClFN₂
Molecular Weight 182.58
Synonym(s) 4-CHLORO-7-FLUORO-QUINAZOLINE
SMILES FC1=CC2=NC=NC(Cl)=C2C=C1

Description

4-Chloro-7-fluoroquinazoline delivers a highly reactive scaffold for medicinal chemistry, combining electron-deficient aromaticity with orthogonal functional handles. This bench-stable heterocycle enables direct coupling and cyclization strategies in kinase inhibitor development, where halogen substitution enhances binding affinity and metabolic stability.

Application

4-Chloro-7-fluoroquinazoline serves as a versatile building block in medicinal chemistry, enabling direct functionalization at the 4- and 7-positions via palladium-catalyzed cross-coupling and nucleophilic substitution reactions. Its orthogonal reactivity profile supports the construction of diverse quinazoline-based scaffolds with high regiocontrol. The molecule exhibits excellent bench stability, facilitates straightforward purification, and functions reliably in standard synthetic workflows for API development and target-oriented synthesis.

Synthesis

Route1
- In-stock
  
  16499-57-3
- ~99%
- In-stock
  
  16499-62-0
References
- Huang, Kenneth He; Veal, James; Barta, Thomas; Smith, Emilie D.; Ma, Wei; Ommen, Andy Patent: US2008/70935 A1, 2008 ; Location in patent: Page/Page column 54 ;

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 25.78
LogP 2.4223
H_Acceptors 2
H_Donors 0
Rotatable_Bonds 0

Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic heterocycle compounds Quinazoline compounds

Key Words

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4-Chloro-7-fluoroquinazoline

CAS No. 16499-62-0

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