4-Chloro-6,7-difluoroquinazoline

Name: 4-Chloro-6,7-difluoroquinazoline
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 625080-60-6
Cat. No. CS-W022153
Purity≥98%
MDL No.MFCD06657230

HazMat Fee +

HazMat Fee

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

The shipment is processed through FedEx Ground under the Limited Quantity option.

Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

4-Chloro-6,7-difluoroquinazoline|CS-W022153

Structure of 625080-60-6

Size

Price

Quantity

* Please select Quantity before adding items.

General Information

CAS No. 625080-60-6
Cat. No. CS-W022153
Purity ≥98%
MDL No. MFCD06657230
Storage -20°C, sealed storage, away from moisture
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₈H₃ClF₂N₂
Molecular Weight 200.57
Synonym(s) 4-chloro-6,7-difluoro-quinazoline
SMILES ClC1=NC=NC2=CC(=C(C=C12)F)F

Description

4-Chloro-6,7-difluoroquinazoline features a highly electron-deficient quinazoline core with orthogonal halogen substituents enabling selective cross-coupling. This bench-stable scaffold integrates readily into bioactive molecules, serving as a key building block for kinase inhibitors and pharmaceutical intermediates.

Application

4-Chloro-6,7-difluoroquinazoline serves as a versatile building block in medicinal chemistry, enabling efficient construction of kinase inhibitors and other bioactive heterocycles. The chloro group at the 4-position facilitates palladium-catalyzed cross-coupling reactions, while the 6,7-difluoro substitution enhances metabolic stability and modulates electronic properties. Its bench-stable nature and compatibility with diverse functional groups make it well-suited for iterative synthesis campaigns and API development.

Synthesis

Route1
- In-stock
  
  205259-37-6
- ~87%
- In-stock
  
  625080-60-6
References
- AMBIT BIOSCIENCES CORPORATON Patent: WO2009/117080 A1, 2009 ; Location in patent: Page/Page column 165 ; WO 2009/117080 A1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

TPSA 25.78
LogP 2.5614
H_Acceptors 2
H_Donors 0
Rotatable_Bonds 0

Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic heterocycle compounds Quinazoline compounds

Drug Discovery Cancer EGFR

Key Words

4-Chloro-6,7-difluoroquinazoline sigma4-Chloro-6,7-difluoroquinazoline manufacturer4-Chloro-6,7-difluoroquinazoline price4-Chloro-6,7-difluoroquinazoline structure4-Chloro-6,7-difluoroquinazoline SDSbuy 4-Chloro-6,7-difluoroquinazoline4-Chloro-6,7-difluoroquinazoline supplier4-Chloro-6,7-difluoroquinazoline uses4-Chloro-6,7-difluoroquinazoline molecular weightprice of 4-Chloro-6,7-difluoroquinazoline4-Chloro-6,7-difluoroquinazoline chemical name formula of 4-Chloro-6,7-difluoroquinazoline

Salutation:	*Country or Region:
*Applicant Name:	*Organization Name:
*Email Address:	Quantity:
CAS NO. :	Product Name:
Remarks:
Upload Pictures

CAS.No.		Product Name
Applicant Name *		Email Address *
Phone Number *		Organization Name*
Country or Region*		Quantity*
Remarks:

Product Name:
Cat. No.: .		CAS NO. :
Quantity:

4-Chloro-6,7-difluoroquinazoline

CAS No. 625080-60-6

Recommended Products