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CS-W001157 4
Total: USD 88.00

4-Chloro-6-fluoroquinazoline

  • CAS No. 16499-61-9

  • Cat. No. CS-D0549
  • Purity≥98%
  • MDL No.MFCD07776652

*For research and further manufacturing use only, not for direct human use.

4-Chloro-6-fluoroquinazoline|CS-D0549

Structure of 16499-61-9

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General Information

  • CAS No. 16499-61-9
  • Cat. No. CS-D0549
  • Purity ≥98%
  • MDL No. MFCD07776652
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₄ClFN₂
  • Molecular Weight 182.58
  • Synonym(s) None
  • SMILES ClC1=NC=NC2=CC=C(F)C=C21

Description

4-Chloro-6-fluoroquinazoline delivers a dual halogenated scaffold ideal for cross-coupling and bioconjugation strategies. The electron-deficient quinazoline core, flanked by chlorine and fluorine at C4 and C6 positions, enhances reactivity in palladium-catalyzed transformations. This bench-stable derivative enables efficient access to functionalized heterocycles in medicinal chemistry and materials synthesis.

Application

4-Chloro-6-fluoroquinazoline serves as a versatile building block in medicinal chemistry, enabling direct functionalization at C4 and C6 positions via palladium-catalyzed cross-coupling or nucleophilic substitution. Its electron-deficient core enhances reactivity in heterocyclic synthesis, while the orthogonal halogenation pattern supports sequential derivatization. Bench-stable and amenable to purification by recrystallization, it facilitates efficient access to kinase inhibitor scaffolds and other bioactive quinazolines in drug discovery workflows.

Synthesis

  • Route1

    References

    • WO2011/11522 A2, ; Page/Page column 56 ; WO 2011/011522 A2
  • Route2

    References

    • WO2011/11522 A2, ; WO 2011/011522 A2

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   25.78
  • LogP   2.4223
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   0

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