4-Chloro-7-fluoro-2-methylquinazoline

Name: 4-Chloro-7-fluoro-2-methylquinazoline
Brand: ChemScene
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CAS No. 1206694-32-7
Cat. No. CS-0102599
Molecule weight196.61
Purity≥97%
MDL No.MFCD12024899

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
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4-Chloro-7-fluoro-2-methylquinazoline|CS-0102599

Structure of 1206694-32-7

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General Information

CAS No. 1206694-32-7
Cat. No. CS-0102599
Purity ≥97%
MDL No. MFCD12024899
Storage -20°C, stored under nitrogen
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₉H₆ClFN₂
Molecular Weight 196.61
Synonym(s) 4-chloro-7-fluoro-2-methyl-quinazoline
SMILES CC1=NC(Cl)=C2C=CC(F)=CC2=N1

Description

4-Chloro-7-fluoro-2-methylquinazoline is a heterocyclic scaffold featuring complementary electron-withdrawing halogens and a methyl group, enabling selective reactivity in medicinal chemistry. This bench-stable compound integrates readily into kinase inhibitor architectures, offering enhanced binding affinity through strategic steric and electronic modulation.

Application

4-Chloro-7-fluoro-2-methylquinazoline serves as a versatile building block in medicinal chemistry, enabling efficient construction of kinase inhibitor scaffolds. Its orthogonal halogenation pattern facilitates palladium-catalyzed cross-coupling reactions with minimal side reactivity. The 2-methyl group enhances metabolic stability and improves solubility profiles. Bench-stable and amenable to standard purification methods, it functions reliably in diverse synthetic workflows for targeted drug discovery programs.

Synthesis

Route1
- 194473-03-5
- ~%
- In-stock
  
  1206694-32-7
References
- Organic Letters, , vol. 12, # 3 p. 552 - 555

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 25.78
LogP 2.73072
H_Acceptors 2
H_Donors 0
Rotatable_Bonds 0

Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic heterocycle compounds Quinazoline compounds

Key Words

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4-Chloro-7-fluoro-2-methylquinazoline

CAS No. 1206694-32-7

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