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CS-W001157 4
Total: USD 88.00

(S)-1-(2,3-Difluorophenyl)ethanamine

  • CAS No. 1415380-62-9

  • Cat. No. CS-0196774
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

(S)-1-(2,3-Difluorophenyl)ethanamine|CS-0196774

Structure of 1415380-62-9

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General Information

  • CAS No. 1415380-62-9
  • Cat. No. CS-0196774
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₉F₂N
  • Molecular Weight 157.16
  • Synonym(s) None
  • SMILES N[C@@H](C)C1=CC=CC(F)=C1F

Description

(S)-1-(2,3-Difluorophenyl)ethanamine features a chiral α-amino center paired with a 2,3-difluorophenyl group, delivering enhanced metabolic stability and improved binding selectivity in bioactive molecule design. This bench-stable, moisture-tolerant amine integrates readily into asymmetric synthesis workflows for pharmaceutical intermediates.

Application

(S)-1-(2,3-Difluorophenyl)ethanamine serves as a valuable chiral building block in medicinal chemistry, enabling the synthesis of enantiopure pharmaceutical intermediates. Its structural motif—featuring a stereogenic center adjacent to a difluorinated aromatic ring—confers enhanced metabolic stability and modulated lipophilicity. The molecule exhibits good bench stability, facilitates straightforward purification via distillation or crystallization, and participates reliably in standard amine functionalizations, including acylation, alkylation, and coupling reactions. This compound functions as a key scaffold for constructing bioactive heterocycles and targeted small-molecule candidates.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 2735
Class : 8
Packing Group : Ⅲ
Hazard Statements : H314
Precautionary Statements : P210-P260-P264-P280-P301+P330+P331-P304+P340-P363-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   26.02
  • LogP   1.9845
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

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