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1-(2,3-Difluorophenyl)ethanamine hydrochloride

  • CAS No. 1427378-79-7

  • Cat. No. CS-0158453
  • Purity≥95%
  • MDL No.MFCD23144080

*For research and further manufacturing use only, not for direct human use.

1-(2,3-Difluorophenyl)ethanamine hydrochloride|CS-0158453

Structure of 1427378-79-7

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General Information

  • CAS No. 1427378-79-7
  • Cat. No. CS-0158453
  • Purity ≥95%
  • MDL No. MFCD23144080
  • Storage Store at room temperature, keep dry and cool
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₀ClF₂N
  • Molecular Weight 193.62
  • Synonym(s) 1-(2,3-Difluorophenyl)ethan-1-amine hydrochloride
  • SMILES C(C)(N)C=1C(=C(C=CC1)F)F.[H]Cl

Description

1-(2,3-Difluorophenyl)ethanamine hydrochloride features a difluorinated aromatic ring paired with a primary amine functionality, enabling direct incorporation into bioactive scaffolds. The hydrochloride salt enhances solubility and stability under standard conditions, facilitating use in medicinal chemistry workflows.

Application

1-(2,3-Difluorophenyl)ethanamine hydrochloride serves as a versatile chiral building block in medicinal chemistry, enabling the synthesis of bioactive molecules through standard amine functionalization. Its difluorophenyl moiety enhances metabolic stability and modulates lipophilicity, while the hydrochloride salt ensures excellent solubility and bench stability. The compound facilitates efficient coupling reactions and is compatible with common protecting group strategies, making it well-suited for multi-step synthesis and API development workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   26.02
  • LogP   2.4063
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

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