(S)-2-Amino-3-(4-(trifluoromethyl)phenyl)propan-1-ol

Name: (S)-2-Amino-3-(4-(trifluoromethyl)phenyl)propan-1-ol
Brand: ChemScene
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CAS No. 153181-07-8
Cat. No. CS-0196817
Purity≥97%
MDL No.None

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FedEx Limited Quantities Ground	$0.00
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(S)-2-Amino-3-(4-(trifluoromethyl)phenyl)propan-1-ol|CS-0196817

Structure of 153181-07-8

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General Information

CAS No. 153181-07-8
Cat. No. CS-0196817
Purity ≥97%
MDL No. None
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₀H₁₂F₃NO
Molecular Weight 219.20
Synonym(s) Benzenepropanol, β-amino-4-(trifluoromethyl)-, (S)- (9CI)
SMILES OC[C@@H](N)CC1=CC=C(C(F)(F)F)C=C1

Description

(S)-2-Amino-3-(4-(trifluoromethyl)phenyl)propan-1-ol is a chiral building block featuring a benzene ring substituted with a trifluoromethyl group and a pendant amino-alcohol functionality. This configuration enables selective incorporation into bioactive scaffolds, particularly in medicinal chemistry applications where stereochemical control is critical. The molecule exhibits enhanced metabolic stability due to the electron-withdrawing trifluoromethyl moiety and demonstrates favorable solubility under standard reaction conditions.

Application

(S)-2-Amino-3-(4-(trifluoromethyl)phenyl)propan-1-ol serves as a valuable chiral building block in medicinal chemistry, enabling the synthesis of bioactive molecules via standard amine and alcohol functional group transformations. Its structural features—chirality, aromatic trifluoromethyl group, and orthogonal functionality—support efficient coupling reactions, derivatization, and incorporation into heterocyclic scaffolds. Bench-stable and compatible with common protecting group strategies, it facilitates scalable route development for API candidates requiring defined stereochemistry and enhanced metabolic stability.

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P362

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Computational Chemistry Data

TPSA 46.25
LogP 1.5675
H_Acceptors 2
H_Donors 2
Rotatable_Bonds 3

Other Classifications

Building Blocks Functional Group Alcohol

Building Blocks Functional Group Fluoride

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

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(S)-2-Amino-3-(4-(trifluoromethyl)phenyl)propan-1-ol

CAS No. 153181-07-8

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