7-(Trifluoromethyl)chroman-4-amine

Name: 7-(Trifluoromethyl)chroman-4-amine
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CAS No. 704208-25-3
Cat. No. CS-0197380
Purity≥97%
MDL No.MFCD11656623

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7-(Trifluoromethyl)chroman-4-amine|CS-0197380

Structure of 704208-25-3

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General Information

CAS No. 704208-25-3
Cat. No. CS-0197380
Purity ≥97%
MDL No. MFCD11656623
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₀H₁₀F₃NO
Molecular Weight 217.19
Synonym(s) 3,4-Dihydro-7-(trifluoromethyl)-2H-1-benzopyran-4-amine
SMILES C1=CC2=C(C=C1C(F)(F)F)OCCC2N

Description

7-(Trifluoromethyl)chroman-4-amine features a trifluoromethyl group at the 7-position and a primary amine at the 4-position of a chroman scaffold. This electron-deficient, bench-stable heterocycle integrates readily into medicinal chemistry campaigns targeting kinase inhibitors and CNS-active compounds. The fluorinated side chain enhances metabolic stability and membrane permeability.

Application

7-(Trifluoromethyl)chroman-4-amine serves as a versatile building block in medicinal chemistry, enabling the synthesis of bioactive chroman derivatives. Its trifluoromethyl group enhances metabolic stability and membrane permeability, while the primary amine facilitates conjugation in standard coupling reactions. The scaffold exhibits bench-stable handling and compatibility with common functional group transformations, making it ideal for lead optimization campaigns in drug discovery.

Safety Information

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Signal Word : N/A	UN#: N/A
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Hazard Statements : N/A
Precautionary Statements : N/A

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Computational Chemistry Data

TPSA 35.25
LogP 2.4877
H_Acceptors 2
H_Donors 1
Rotatable_Bonds 0

Other Classifications

Building Blocks Functional Group Fluoride

Building Blocks Skeleton Aromatic heterocycle compounds Other aromatic heterocycles compounds

Key Words

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7-(Trifluoromethyl)chroman-4-amine

CAS No. 704208-25-3

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