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CS-W001157 4
Total: USD 88.00

Mal-PEG2-acid

  • CAS No. 1374666-32-6

  • Cat. No. CS-0107943
  • Purity≥97%
  • MDL No.MFCD23726620

*For research and further manufacturing use only, not for direct human use.

Mal-PEG2-acid|CS-0107943

Structure of 1374666-32-6

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General Information

  • CAS No. 1374666-32-6
  • Cat. No. CS-0107943
  • Purity ≥97%
  • MDL No. MFCD23726620
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₁₅NO₆
  • Molecular Weight 257.24
  • Synonym(s) None
  • SMILES O=C(O)CCOCCOCCN1C(C=CC1=O)=O

Description

Mal-PEG2-acid features a maleimide group conjugated to a short PEG2 spacer terminating in a carboxylic acid. This bifunctional architecture enables site-specific bioconjugation via thiol-Michael addition, followed by facile coupling to amine-containing biomolecules under standard conditions. The PEG2 linker imparts enhanced solubility and reduced aggregation, improving handling in aqueous environments.

Application

Mal-PEG2-acid serves as a versatile bifunctional linker for conjugation and bioconjugation workflows. The maleimide group enables site-specific, thiol-selective coupling under physiological conditions, while the terminal carboxylic acid facilitates amine-based conjugation or further derivatization. PEG2 spacer provides enhanced solubility and reduced steric hindrance, improving reactivity and stability in aqueous environments. Ideal for antibody-drug conjugates, peptide modifications, and surface functionalization.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P405-P501

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Computational Chemistry Data

  • TPSA   93.14
  • LogP   -0.5807
  • H_Acceptors   5
  • H_Donors   1
  • Rotatable_Bonds   9

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