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CS-W001157 4
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Boc-NH-PEG2-CH2CH2COOH

  • CAS No. 1365655-91-9

  • Cat. No. CS-0067115
  • Purity≥97%
  • MDL No.MFCD22056304

*For research and further manufacturing use only, not for direct human use.

Boc-NH-PEG2-CH2CH2COOH|CS-0067115

Structure of 1365655-91-9

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General Information

  • CAS No. 1365655-91-9
  • Cat. No. CS-0067115
  • Purity ≥97%
  • MDL No. MFCD22056304
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₂₃NO₆
  • Molecular Weight 277.31
  • Synonym(s) None
  • SMILES CC(C)(C)OC(NCCOCCOCCC(O)=O)=O

Description

Boc-NH-PEG2-CH2CH2COOH features a protected amine linked to a two-unit polyethylene glycol spacer terminating in a reactive carboxylic acid. This bifunctional construct enables site-specific conjugation in bioconjugation workflows, with the Boc group providing stability during handling and storage. The PEG2 spacer enhances solubility and reduces aggregation in aqueous environments.

Application

Boc-NH-PEG2-CH₂CH₂COOH serves as a versatile bifunctional linker for peptide and conjugate synthesis, combining the stability of a Boc-protected amine with a two-ether unit PEG spacer and a terminal carboxylic acid. The PEG2 segment enhances solubility in aqueous and organic media, while the carboxylic acid facilitates coupling reactions with amines via standard activation protocols. This reagent enables efficient construction of bioconjugates, peptide-drug hybrids, and functionalized polymers with improved solubility and reduced aggregation.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   94.09
  • LogP   1.019
  • H_Acceptors   5
  • H_Donors   2
  • Rotatable_Bonds   9

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