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CS-W001157 4
Total: USD 88.00

Fmoc-NH-PEG2-CH2CH2COOH

  • CAS No. 872679-70-4

  • Cat. No. CS-W020978
  • Purity≥95%
  • MDL No.MFCD08064306

*For research and further manufacturing use only, not for direct human use.

Fmoc-NH-PEG2-CH2CH2COOH|CS-W020978

Structure of 872679-70-4

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General Information

  • CAS No. 872679-70-4
  • Cat. No. CS-W020978
  • Purity ≥95%
  • MDL No. MFCD08064306
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₂H₂₅NO₆
  • Molecular Weight 399.44
  • Synonym(s) None
  • SMILES O=C(O)CCOCCOCCNC(OCC1C2=C(C3=C1C=CC=C3)C=CC=C2)=O

Description

Fmoc-NH-PEG2-CH2CH2COOH features a fluorenylmethoxy carbonyl (Fmoc) protected amine linked to a two-unit polyethylene glycol spacer, terminating in a reactive carboxylic acid. This bifunctional architecture enables efficient conjugation strategies in peptide synthesis and bioconjugation workflows. The PEG2 spacer provides enhanced solubility and reduced aggregation, while the terminal carboxylic acid facilitates coupling under standard activation conditions.

Application

Fmoc-NH-PEG2-CH₂CH₂COOH serves as a versatile bifunctional linker for peptide synthesis and bioconjugation. The Fmoc group enables efficient N-terminal protection during solid-phase peptide coupling, while the terminal carboxylic acid facilitates amide bond formation with amines. The PEG₂ spacer provides enhanced solubility and reduced aggregation, improving reaction efficiency and purification. This compound exhibits excellent bench stability and functional group compatibility in standard synthetic workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   94.09
  • LogP   3.033
  • H_Acceptors   5
  • H_Donors   2
  • Rotatable_Bonds   11

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