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CS-W001157 4
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Benzyl (cis-3-(methylamino)cyclobutyl)carbamate

  • CAS No. 1353501-22-0

  • Cat. No. CS-0372313
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

Benzyl (cis-3-(methylamino)cyclobutyl)carbamate|CS-0372313

Structure of 1353501-22-0

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General Information

  • CAS No. 1353501-22-0
  • Cat. No. CS-0372313
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₃H₁₈N₂O₂
  • Molecular Weight 234.29
  • Synonym(s) None
  • SMILES O=C(OCC1=CC=CC=C1)N[C@H]2C[C@@H](NC)C2

Description

Benzyl (cis-3-(methylamino)cyclobutyl)carbamate features a cis-configured cyclobutyl scaffold bearing a methylamino group, enabling precise spatial control in molecular design. This bench-stable carbamate integrates readily into peptide-like architectures and serves as a protected amine surrogate in synthetic applications requiring conformational restraint and enhanced metabolic stability.

Application

Benzyl (cis-3-(methylamino)cyclobutyl)carbamate serves as a stable, bench-friendly carbamate protecting group for primary amines, enabling selective functionalization within complex molecular architectures. The cis-cyclobutyl scaffold imparts conformational rigidity, enhancing stereochemical control in downstream transformations. Its compatibility with standard deprotection conditions and tolerance to diverse reaction environments make it particularly useful in medicinal chemistry workflows involving cyclic amine derivatives and heterocyclic API intermediates.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   50.36
  • LogP   1.6632
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   4

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