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CS-W001157 4
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tert-Butyl N-[2-(methylamino)ethyl]carbamate

  • CAS No. 122734-32-1

  • Cat. No. CS-W008686
  • Purity≥95%
  • MDL No.MFCD06808585

*For research and further manufacturing use only, not for direct human use.

tert-Butyl N-[2-(methylamino)ethyl]carbamate|CS-W008686

Structure of 122734-32-1

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General Information

  • CAS No. 122734-32-1
  • Cat. No. CS-W008686
  • Purity ≥95%
  • MDL No. MFCD06808585
  • Storage RT, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₈N₂O₂
  • Molecular Weight 174.24
  • Synonym(s) tert-Butyl N-(2-Methylaminoethyl)carbamate
  • SMILES O=C(NCCNC)OC(C)(C)C

Description

tert-Butyl N-[2-(methylamino)ethyl]carbamate features a protected amine handle ideal for peptide synthesis and bioconjugation. The tert-butyl carbamate group enables mild deprotection under acidic conditions, while the primary methylaminoethyl side chain offers a reactive site for functionalization. This bifunctional scaffold integrates seamlessly into complex molecular architectures.

Application

tert-Butyl N-[2-(methylamino)ethyl]carbamate serves as a bifunctional building block in medicinal chemistry, enabling the sequential introduction of amine and carbamate handles. The tertiary amine moiety facilitates salt formation and solubility modulation, while the tert-butyl carbamate group offers robust protection for primary amines under standard conditions. This compound functions reliably in multi-step synthesis, supporting efficient deprotection with trifluoroacetic acid and demonstrating excellent bench stability and compatibility with diverse reaction types.

Synthesis

  • Route1
    • tert-Butyl (2-(benzyl(methyl)amino)ethyl)carbamate|CS-0673009
      849472-99-7
    • ~91%
    • In-stock
      tert-Butyl N-[2-(methylamino)ethyl]carbamate|CS-W008686
      122734-32-1

    References

    • US2011/262355 A1, ; Page/Page column 136 ;
  • Route2
    • In-stock
      Di-tert-butyl dicarbonate|CS-0017817
      24424-99-5
    • null|null
      109-81-9
    • ~18%
    • In-stock
      tert-Butyl N-[2-(methylamino)ethyl]carbamate|CS-W008686
      122734-32-1

    References

    • EP1864968 A1, ; Page/Page column 18-19 ;
  • Route3
    • null|null
      39684-80-5
    • null|null
      74-89-5
    • ~81%
    • In-stock
      tert-Butyl N-[2-(methylamino)ethyl]carbamate|CS-W008686
      122734-32-1

    References

    • Organic Preparations and Procedures International, , vol. 41, # 4 p. 301 - 307

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   50.36
  • LogP   0.7305
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   3

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