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CS-W001157 4
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tert-Butyl (3-aminocyclobutyl)carbamate

  • CAS No. 1090904-48-5

  • Cat. No. CS-W005385
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

tert-Butyl (3-aminocyclobutyl)carbamate|CS-W005385

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General Information

  • CAS No. 1090904-48-5
  • Cat. No. CS-W005385
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₈N₂O₂
  • Molecular Weight 186.25
  • Synonym(s) TERT-BUTYL 3-AMINOCYCLOBUTYLCARBAMATE
  • SMILES O=C(OC(C)(C)C)NC1CC(N)C1

Description

tert-Butyl (3-aminocyclobutyl)carbamate delivers a rigid, conformationally constrained cyclobutyl scaffold bearing a protected amine. This stable, bench-ready building block integrates readily into medicinal chemistry campaigns requiring defined stereochemistry and metabolic resistance.

Application

tert-Butyl (3-aminocyclobutyl)carbamate serves as a versatile building block in medicinal and process chemistry, enabling the efficient construction of cyclobutane-containing scaffolds. The tert-butyl carbamate group provides excellent stability under basic conditions and mild cleavage with acid, facilitating controlled deprotection. The pendant primary amine supports diverse functionalization—such as acylation, alkylation, and coupling reactions—while the constrained cyclobutyl ring offers defined stereochemistry and conformational rigidity beneficial for target-oriented synthesis.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   64.35
  • LogP   1.0008
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   1

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