cis-tert-Butyl 3-aminocyclobutanecarbamate

Name: cis-tert-Butyl 3-aminocyclobutanecarbamate
Brand: ChemScene
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CAS No. 1212395-34-0
Cat. No. CS-0045544
Purity≥97%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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cis-tert-Butyl 3-aminocyclobutanecarbamate|CS-0045544

Structure of 1212395-34-0

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General Information

CAS No. 1212395-34-0
Cat. No. CS-0045544
Purity ≥97%
MDL No. None
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₉H₁₈N₂O₂
Molecular Weight 186.25
Synonym(s) tert-Butyl (3-aminocyclobutyl)carbamate
SMILES O=C(OC(C)(C)C)N[C@H]1C[C@@H](N)C1

Description

cis-tert-Butyl 3-aminocyclobutanecarbamate features a rigid, conformationally constrained cyclobutane core with a strategically positioned amine and carbamate group. This configuration enables precise spatial control in synthetic applications, facilitating efficient incorporation into complex molecular architectures under standard conditions.

Application

cis-tert-Butyl 3-aminocyclobutanecarbamate serves as a conformationally constrained, bench-stable building block for medicinal chemistry and peptide mimicry. The protected amine and carbamate functionalities enable orthogonal transformations, while the cyclobutane scaffold imparts rigidity useful in modulating bioactive molecule geometry. It functions effectively in standard coupling reactions and serves as a key intermediate in the synthesis of heterocyclic scaffolds and targeted API candidates.

Synthesis

Route1
- 1239589-57-1
- ~87%
- In-stock
  
  1212395-34-0
References
- Radchenko, Dmytro S.; Pavlenko, Sergiy O.; Grygorenko, Oleksandr O.; Volochnyuk, Dmitriy M.; Shishkina, Svitlana V.; Shishkin, Oleg V.; Komarov, Igor V. Journal of Organic Chemistry, 2010 , vol. 75, # 17 p. 5941 - 5952
Route2
- 871014-17-4
- ~%
- In-stock
  
  1212395-34-0
References
- US2013/225552 A1, ;

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

TPSA 64.35
LogP 1.0008
H_Acceptors 3
H_Donors 2
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Amine

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Building Blocks Skeleton Fatty ring compounds Cyclobutane compounds

Key Words

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cis-tert-Butyl 3-aminocyclobutanecarbamate

CAS No. 1212395-34-0

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