(S)-2-(Morpholin-2-yl)acetic acid hydrochloride

Name: (S)-2-(Morpholin-2-yl)acetic acid hydrochloride
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CAS No. 1352709-57-9
Cat. No. CS-0155209
Purity≥95%
MDL No.MFCD13194714

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(S)-2-(Morpholin-2-yl)acetic acid hydrochloride|CS-0155209

Structure of 1352709-57-9

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General Information

CAS No. 1352709-57-9
Cat. No. CS-0155209
Purity ≥95%
MDL No. MFCD13194714
Storage 4°C, sealed storage, away from moisture
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₁₂ClNO₃
Molecular Weight 181.62
Synonym(s) 2-((S)-morpholin-2-yl)acetic acid HCl
SMILES C1CO[C@@H](CC(=O)O)CN1.Cl

Description

(S)-2-(Morpholin-2-yl)acetic acid hydrochloride features a chiral morpholine-bearing side chain, offering enhanced solubility and metabolic stability. This bench-stable derivative integrates readily into peptide-based conjugates and bioactive molecule scaffolds. The hydrochloride salt form improves handling and crystallization behavior in synthetic workflows.

Application

(S)-2-(Morpholin-2-yl)acetic acid hydrochloride serves as a versatile chiral building block in medicinal chemistry, enabling the synthesis of bioactive molecules through established amide and ester coupling reactions. Its morpholine moiety provides enhanced solubility and hydrogen-bonding capacity, while the α-chiral center supports stereoselective transformations. The hydrochloride salt ensures excellent bench stability and ease of handling, facilitating purification and integration into multi-step synthetic sequences.

Safety Information

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Signal Word : N/A	UN#: N/A
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Computational Chemistry Data

TPSA 58.56
LogP -0.1287
H_Acceptors 3
H_Donors 2
Rotatable_Bonds 2

Other Classifications

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Building Blocks Skeleton Aliphatic heterocycle compounds Morpholine compounds

Key Words

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(S)-2-(Morpholin-2-yl)acetic acid hydrochloride

CAS No. 1352709-57-9

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