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CS-W001157 4
Total: USD 88.00

4-(4'-Fluorobenzyl)piperidine

  • CAS No. 92822-02-1

  • Cat. No. CS-W021997
  • Molecule weight193.26
  • Purity≥98%
  • MDL No.MFCD03839825

*For research and further manufacturing use only, not for direct human use.

4-(4'-Fluorobenzyl)piperidine|CS-W021997

Structure of 92822-02-1

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General Information

  • CAS No. 92822-02-1
  • Cat. No. CS-W021997
  • Purity ≥98%
  • MDL No. MFCD03839825
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₁₆FN
  • Molecular Weight 193.26
  • Synonym(s) 4-(4-Fluorobenzyl)piperidine
  • SMILES FC1=CC=C(CC2CCNCC2)C=C1

Description

4-(4'-Fluorobenzyl)piperidine features a fluorinated benzyl group attached to the piperidine ring, delivering enhanced metabolic stability and improved membrane permeability. This structural motif enables efficient integration into bioactive molecules, particularly in CNS-targeted pharmaceuticals and kinase inhibitors. The para-fluoro substitution imparts favorable electronic and lipophilic properties for drug design.

Application

4-(4'-Fluorobenzyl)piperidine serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive scaffolds through its readily functionalizable piperidine core and orthogonal fluoroaryl handle. The molecule exhibits excellent bench stability, facilitates efficient derivatization via alkylation or coupling reactions, and supports high functional group tolerance—making it well-suited for iterative synthesis campaigns targeting CNS-directed therapeutics and kinase inhibitors.

Synthesis

  • Route1
    • null|null
      193357-62-9
    • ~%
    • In-stock
      4-(4'-Fluorobenzyl)piperidine|CS-W021997
      92822-02-1

    References

    • Journal of Medicinal Chemistry, , vol. 47, # 8 p. 2089 - 2096
  • Route2
    • 1-[4-(4-Fluorobenzoyl)-1-piperidinyl]ethanone|CS-0647731
      25519-77-1
    • In-stock
      1-Acetylpiperidine-4-carboxylic acid|CS-0011192
      25503-90-6
    • ~%
    • In-stock
      4-(4'-Fluorobenzyl)piperidine|CS-W021997
      92822-02-1

    References

    • US4690931 A1, ;
  • Route3
    • null|null
      276872-81-2
    • ~97%
    • In-stock
      4-(4'-Fluorobenzyl)piperidine|CS-W021997
      92822-02-1

    References

    • Ting, Pauline C.; Lee, Joe F.; Wu, Jie; Umland, Shelby P.; Aslanian, Robert; Cao, Jianhua; Dong, Youhao; Garlisi, Charles G.; Gilbert, Eric J.; Huang, Ying; Jakway, James; Kelly, Joseph; Liu, Zhidan; McCombie, Stuart; Shah, Himanshu; Tian, Fang; Wan, Yuntao; Shih, Neng-Yang Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 5 p. 1375 - 1378

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   12.03
  • LogP   2.3678
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   2

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