Tel:

Email:

EN
Cat. No. Size / Unit Price Qty
CS-W001157 4
Total: USD 88.00

4-Fluoro-3-hydroxybenzaldehyde

  • CAS No. 103438-85-3

  • Cat. No. CS-0131173
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

4-Fluoro-3-hydroxybenzaldehyde|CS-0131173

Structure of 103438-85-3

Please choose your location and provide accurate information for you
Size Stock
Price Quantity

* Please select Quantity before adding items.

General Information

  • CAS No. 103438-85-3
  • Cat. No. CS-0131173
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₅FO₂
  • Molecular Weight 140.11
  • Synonym(s) 3-hydroxy-4-fluoro-benzaldehyde
  • SMILES O=CC1=CC=C(F)C(O)=C1

Description

4-Fluoro-3-hydroxybenzaldehyde features a strategically positioned aldehyde group flanked by electron-withdrawing fluorine and hydrogen-bonding hydroxyl functionalities. This combination enhances reactivity in nucleophilic addition reactions while maintaining stability under standard bench conditions. The ortho-hydroxyl enables chelation with metal catalysts, facilitating efficient transition-metal-coupled transformations. A valuable scaffold for synthesizing bioactive heterocycles and functionalized aromatic intermediates.

Application

4-Fluoro-3-hydroxybenzaldehyde serves as a versatile building block in medicinal chemistry, enabling direct functionalization at the phenolic hydroxyl and aldehyde groups. Its ortho-hydroxyfluoro substitution pattern facilitates intramolecular cyclizations and enhances metabolic stability in target scaffolds. The compound exhibits good bench stability and compatibility with common protecting group strategies, allowing for efficient diversification in multi-step syntheses.

Synthesis

  • Route1

    References

    • Eisai Co., Ltd. Patent: US2006/4013 A1, 2006 ; Location in patent: Page/Page column 51 ; US 20060004013 A1
  • Route2
    • 4-(Dimethoxymethyl)-1-fluoro-2-nitrobenzene|CS-1202469
      311464-46-7
    • ~%
    • In-stock
      4-Fluoro-3-hydroxybenzaldehyde|CS-0131173
      103438-85-3

    References

    • Journal of Medicinal Chemistry, , vol. 29, # 10 p. 1982 - 1988
  • Route3

    References

    • Bioorganic and Medicinal Chemistry, , vol. 9, # 3 p. 677 - 694

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

  • TPSA   37.3
  • LogP   1.3438
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

Other Classifications

Recently Viewed Products

Leave US a Message
Upload Pictures

Key Words

  • 4-Fluoro-3-hydroxybenzaldehyde sigma4-Fluoro-3-hydroxybenzaldehyde manufacturer4-Fluoro-3-hydroxybenzaldehyde price4-Fluoro-3-hydroxybenzaldehyde structure4-Fluoro-3-hydroxybenzaldehyde SDSbuy 4-Fluoro-3-hydroxybenzaldehyde4-Fluoro-3-hydroxybenzaldehyde supplier4-Fluoro-3-hydroxybenzaldehyde uses4-Fluoro-3-hydroxybenzaldehyde molecular weightprice of 4-Fluoro-3-hydroxybenzaldehyde4-Fluoro-3-hydroxybenzaldehyde chemical name formula of 4-Fluoro-3-hydroxybenzaldehyde
This product is not sold in the region.
Confirm
How to get a Lot Number

Lot numbers can be found on the outside label of a product:

ChemScene Label