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CS-W001157 4
Total: USD 88.00

2,4-Difluoro-3-hydroxybenzaldehyde

  • CAS No. 192927-69-8

  • Cat. No. CS-W021514
  • Purity≥97%
  • MDL No.MFCD12405741

*For research and further manufacturing use only, not for direct human use.

2,4-Difluoro-3-hydroxybenzaldehyde|CS-W021514

Structure of 192927-69-8

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General Information

  • CAS No. 192927-69-8
  • Cat. No. CS-W021514
  • Purity ≥97%
  • MDL No. MFCD12405741
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₄F₂O₂
  • Molecular Weight 158.10
  • Synonym(s) Benzaldehyde, 2,4-difluoro-3-hydroxy- (9CI)
  • SMILES O=CC1=CC=C(F)C(O)=C1F

Description

2,4-Difluoro-3-hydroxybenzaldehyde features a strategically positioned aldehyde group flanked by two fluorine atoms and a phenolic hydroxyl, enabling direct incorporation into bioactive scaffolds. The electron-withdrawing fluorines enhance electrophilicity at the carbonyl carbon, while the adjacent hydroxyl supports hydrogen bonding in target interactions. This combination delivers enhanced reactivity in coupling reactions and improved solubility under standard conditions.

Application

2,4-Difluoro-3-hydroxybenzaldehyde serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling efficient access to fluorinated aromatic scaffolds. Its hydroxyl and aldehyde functionalities offer orthogonal reactivity for coupling, derivatization, and heterocycle formation. The molecule exhibits good bench stability and facilitates straightforward purification, making it well-suited for multi-step synthetic sequences requiring functional group tolerance and predictable reactivity.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   37.3
  • LogP   1.4829
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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