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CS-W001157 4
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1-(4-Fluoro-3-hydroxyphenyl)ethanone

  • CAS No. 949159-95-9

  • Cat. No. CS-0038295
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

1-(4-Fluoro-3-hydroxyphenyl)ethanone|CS-0038295

Structure of 949159-95-9

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General Information

  • CAS No. 949159-95-9
  • Cat. No. CS-0038295
  • Purity ≥98%
  • MDL No. None
  • Storage RT, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₇FO₂
  • Molecular Weight 154.14
  • Synonym(s) 1-(4-fluoro-3-hydroxyphenyl)ethan-1-one
  • SMILES CC(=O)C1=CC(=C(C=C1)F)O

Description

1-(4-Fluoro-3-hydroxyphenyl)ethanone features a phenolic hydroxyl group flanked by electron-withdrawing fluorine and carbonyl functionalities, enabling selective functionalization in synthetic intermediates. This bench-stable ketone integrates readily into bioactive molecule scaffolds requiring polar, electron-deficient aryl motifs.

Application

1-(4-Fluoro-3-hydroxyphenyl)ethanone serves as a versatile building block for pharmaceutical intermediates, enabling direct incorporation into biologically active scaffolds. Its phenolic hydroxyl group facilitates regioselective derivatization, while the ketone functionality supports nucleophilic additions and condensation reactions. Bench-stable and compatible with standard purification methods, it functions effectively in late-stage functionalization and heterocycle synthesis under routine reaction conditions.

Synthesis

  • Route1

    References

    • AMGEN INC.; MEMORY PHARMACEUTICALS CORPORATION Patent: WO2007/103260 A1, 2007 ; Location in patent: Page/Page column 64 ; WO 2007/103260 A1
  • Route2

    References

    • CRYPTOPHARMA PTY LTD Patent: WO2008/124878 A1, 2008 ; Location in patent: Page/Page column 128-129 ;
  • Route3

    References

    • Ramseier, Markus; Senn, Paul; Wirz, Jakob Journal of Physical Chemistry A, 2003 , vol. 107, # 18 p. 3305 - 3315

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   37.3
  • LogP   1.7339
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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