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CS-W001157 4
Total: USD 88.00

2-Hydroxymethylmorpholine-4-carboxylic acid tert-butyl ester

  • CAS No. 135065-69-9

  • Cat. No. CS-W008806
  • Purity≥97%
  • MDL No.MFCD03426270

*For research and further manufacturing use only, not for direct human use.

2-Hydroxymethylmorpholine-4-carboxylic acid tert-butyl ester|CS-W008806

Structure of 135065-69-9

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General Information

  • CAS No. 135065-69-9
  • Cat. No. CS-W008806
  • Purity ≥97%
  • MDL No. MFCD03426270
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₉NO₄
  • Molecular Weight 217.26
  • Synonym(s) N-tert-Butoxycarbonyl-2-(hydroxymethyl)morpholine; tert-Butyl 2-(hydroxymethyl)-4-morpholinecarboxylate; Tert-butyl 2-(hydroxymethyl)morpholine-4-carboxylate
  • SMILES O=C(N1CC(CO)OCC1)OC(C)(C)C

Description

This tert-butyl ester derivative of 2-hydroxymethylmorpholine-4-carboxylic acid features a stable, moisture-tolerant protecting group that simplifies handling and storage. The pendant hydroxymethyl moiety enables selective functionalization, while the morpholine core provides a rigid, polar scaffold ideal for medicinal chemistry applications.

Synthesis

  • Route1

    References

    • US2004/192653 A1, ; US 20040192653 A1
  • Route2

    References

    • WO2007/58850 A2, ; Page/Page column 43 ; WO 2007/058850 A2
  • Route3

    References

    • WO2013/91773 A1, ; Page/Page column 64 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   59
  • LogP   0.6146
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   1

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