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Morpholin-2-ylmethanol

  • CAS No. 103003-01-6

  • Cat. No. CS-0106282
  • Molecule weight117.15
  • Purity≥95%
  • MDL No.MFCD03426271

*For research and further manufacturing use only, not for direct human use.

Morpholin-2-ylmethanol|CS-0106282

Structure of 103003-01-6

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General Information

  • CAS No. 103003-01-6
  • Cat. No. CS-0106282
  • Purity ≥95%
  • MDL No. MFCD03426271
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₁₁NO₂
  • Molecular Weight 117.15
  • Synonym(s) None
  • SMILES OCC1CNCCO1

Description

Morpholin-2-ylmethanol features a morpholine ring tethered to a primary alcohol group, delivering enhanced solubility and hydrogen-bonding capacity. This combination enables efficient integration into bioactive molecules, particularly in medicinal chemistry scaffolds where polarity and metabolic stability are critical. The hydroxymethyl functionality facilitates further derivatization under standard conditions.

Application

Morpholin-2-ylmethanol serves as a versatile building block in medicinal chemistry, enabling efficient construction of morpholine-containing scaffolds through straightforward functional group transformations. Its bench-stable nature and compatibility with standard coupling protocols facilitate integration into diverse synthetic routes. The molecule functions as a key intermediate for bioactive compounds, particularly those requiring polar, hydrogen-bonding moieties to enhance solubility and target engagement.

Synthesis

  • Route1

    References

    • PHARMACOPEIA, INC. Patent: WO2004/33440 A1, 2004 ; Location in patent: Page 173 ; WO 2004/033440 A1
  • Route2

    References

    • Kojima; Niigata; Fujikura; et al. Chemical and Pharmaceutical Bulletin, 1985 , vol. 33, # 9 p. 3766 - 3774
  • Route3
    • (9H-Fluoren-9-yl)methyl 2-(hydroxymethyl)morpholine-4-carboxylate|CS-1303582
      885953-31-1
    • ~%
    • In-stock
      Morpholin-2-ylmethanol|CS-0106282
      103003-01-6

    References

    • Bioorganic and Medicinal Chemistry Letters, , vol. 19, # 18 p. 5440 - 5443

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   41.49
  • LogP   -1.0329
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   1

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