Lot numbers can be found on the outside label of a product:
Methyl N-Boc-piperidine-3-carboxylate
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CAS No. 148763-41-1
- Cat. No. CS-0020052
- Purity≥97%
- MDL No.MFCD06795926
*For research and further manufacturing use only, not for direct human use.
Structure of 148763-41-1
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General Information
- CAS No. 148763-41-1
- Cat. No. CS-0020052
- Purity ≥97%
- MDL No. MFCD06795926
- Storage Store at room temperature
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₁₂H₂₁NO₄
- Molecular Weight None
- Synonym(s) TERT-BUTYL METHYL PIPERIDINE-1,3-DICARBOXYLATE
- SMILES O=C(N1CC(C(OC)=O)CCC1)OC(C)(C)C
Description
Methyl N-Boc-piperidine-3-carboxylate is a bench-stable, moisture-tolerant building block featuring a protected piperidine core and ester functionality. This versatile intermediate integrates readily into synthetic sequences requiring nitrogen-directed cyclizations or selective functionalization at the 3-position. The Boc group enables straightforward deprotection under mild acidic conditions, while the methyl ester supports diverse transformations including reduction, hydrolysis, or coupling reactions.
Application
Methyl N-Boc-piperidine-3-carboxylate serves as a versatile building block in medicinal chemistry, enabling efficient access to piperidine-based scaffolds. The Boc-protected amine and ester functionalities offer orthogonal reactivity, facilitating selective transformations during multistep synthesis. Its bench-stable nature and compatibility with standard coupling and reduction protocols make it well-suited for iterative functionalization and heterocycle construction in API development.
Synthesis
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Route1
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71381-75-4 -
18107-18-1
- ~84%
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In-stock
148763-41-1
References
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WARNER-LAMBERT COMPANY LLC Patent: US2006/116376 A1, 2006 ; Location in patent: Page/Page column 16 ;
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Route2
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71381-75-4
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74-88-4
- ~%
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In-stock
148763-41-1
References
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Bioorganic and Medicinal Chemistry Letters, , vol. 14, # 17 p. 4453 - 4459
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Route3
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In-stock
59-67-6 - ~%
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In-stock
148763-41-1
References
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Tetrahedron Asymmetry, , vol. 18, # 2 p. 181 - 191
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 55.84
- LogP 1.8065
- H_Acceptors 4
- H_Donors 0
- Rotatable_Bonds 1
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Key Words
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