Lot numbers can be found on the outside label of a product:
(S)-Morpholin-2-ylmethanol
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CAS No. 132073-83-7
- Cat. No. CS-0020036
- Purity≥97%
- MDL No.MFCD09260718
*For research and further manufacturing use only, not for direct human use.
Structure of 132073-83-7
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General Information
- CAS No. 132073-83-7
- Cat. No. CS-0020036
- Purity ≥97%
- MDL No. MFCD09260718
- Storage 4°C
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₅H₁₁NO₂
- Molecular Weight 117.15
- Synonym(s) (2S)-2-Morpholinemethanol; (2S)-Morpholin-2-ylmethanol; (S)-1-Morpholin-2-ylmethanol; (S)-Morpholin-2-ylmethanol; (S)-Morpholine-2-methanol; (S)-morpholin-2-ylmethanol HCL
- SMILES OC[C@@H]1CNCCO1
Description
(S)-Morpholin-2-ylmethanol is a chiral building block featuring a morpholine ring fused to a primary alcohol group. This configuration enables selective incorporation into bioactive molecules, particularly in medicinal chemistry scaffolds requiring stereochemical control. The hydroxymethyl functionality facilitates downstream derivatization via esterification or ether formation. Stable under standard handling conditions and compatible with common organic solvents, it supports efficient integration into multi-step synthesis workflows without degradation.
Application
(S)-Morpholin-2-ylmethanol serves as a versatile chiral building block in medicinal chemistry, enabling the construction of bioactive heterocycles through established functional group transformations. Its morpholinylmethyl motif exhibits favorable solubility, metabolic stability, and hydrogen-bonding capacity, making it well-suited for drug discovery applications. The compound demonstrates excellent bench stability and compatibility with standard synthetic protocols, facilitating straightforward incorporation into complex molecular architectures.
Synthesis
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Route1
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In-stock
132073-82-6 - ~88%
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In-stock
132073-83-7
References
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WO2012/160392 A1, ; Page/Page column 48 ; WO 2012/160392 A1
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Route2
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In-stock
847805-30-5 - ~84%
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In-stock
132073-83-7
References
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Organic Letters, , vol. 7, # 5 p. 937 - 939
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Route3
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205242-66-6 - ~21%
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In-stock
132073-83-7
References
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Journal of Medicinal Chemistry, , vol. 41, # 11 p. 1934 - 1942
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 41.49
- LogP -1.0329
- H_Acceptors 3
- H_Donors 2
- Rotatable_Bonds 1
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Key Words
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