Lot numbers can be found on the outside label of a product:
(R)-(1-Methylpiperidin-3-yl)methanol
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CAS No. 205194-11-2
- Cat. No. CS-B0137
- Purity≥97%
- MDL No.MFCD11035735
*For research and further manufacturing use only, not for direct human use.
Structure of 205194-11-2
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General Information
- CAS No. 205194-11-2
- Cat. No. CS-B0137
- Purity ≥97%
- MDL No. MFCD11035735
- Storage 4°C
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₇H₁₅NO
- Molecular Weight 129.20
- Synonym(s) 3-Piperidinemethanol,1-methyl-,(3R)-(9CI)
- SMILES CN(CCC1)C[C@@H]1CO
Description
(R)-(1-Methylpiperidin-3-yl)methanol is a chiral building block featuring a stereodefined piperidine core with a methanol handle at the 3-position. This configuration enables selective incorporation into bioactive molecules, where the pendant hydroxyl group facilitates downstream derivatization. The molecule exhibits bench-stable handling and compatibility with diverse synthetic transformations.
Application
(R)-(1-Methylpiperidin-3-yl)methanol serves as a versatile chiral building block in medicinal chemistry, enabling efficient access to bioactive heterocycles. Its tertiary alcohol functionality offers reliable derivatization potential, while the piperidine core provides favorable solubility and metabolic stability. The stereochemistry at C3 ensures predictable reactivity in asymmetric synthesis, facilitating incorporation into API scaffolds with high enantiomeric fidelity. Bench-stable and compatible with standard purification methods, it functions effectively in multistep synthetic sequences.
Synthesis
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Route1
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In-stock
116574-71-1 - ~97%
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In-stock
205194-11-2
References
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BIOVITRUM AB (PUBL) Patent: WO2009/71658 A1, 2009 ; Location in patent: Page/Page column 33-34 ; WO 2009/071658 A1
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Route2
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In-stock
5166-67-6 - ~95%
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In-stock
205194-11-2
References
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Zeneca Limited; Zeneca Pharma S.A. Patent: US6414148 B1, 2002 ; US 6414148 B1
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Route3
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205194-12-3 - ~94%
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In-stock
205194-11-2
References
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Hennequin, Laurent F.; Stokes, Elaine S. E.; Thomas, Andrew P.; Johnstone, Craig; Ple, Patrick A.; Ogilvie, Donald J.; Dukes, Michael; Wedge, Stephen R.; Kendrew, Jane; Curwen, Jon O. Journal of Medicinal Chemistry, 2002 , vol. 45, # 6 p. 1300 - 1312
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H315-H319
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Precautionary Statements : P264-P280-P302+P352-P362+P364
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Quality Control
Computational Chemistry Data
- TPSA 23.47
- LogP 0.3205
- H_Acceptors 2
- H_Donors 1
- Rotatable_Bonds 1
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Key Words
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