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CS-W001157 4
Total: USD 88.00

3-Bromo-4-iodophenol

  • CAS No. 1037298-05-7

  • Cat. No. CS-0098632
  • Purity≥98%
  • MDL No.MFCD17000017

*For research and further manufacturing use only, not for direct human use.

3-Bromo-4-iodophenol|CS-0098632

Structure of 1037298-05-7

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General Information

  • CAS No. 1037298-05-7
  • Cat. No. CS-0098632
  • Purity ≥98%
  • MDL No. MFCD17000017
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₄BrIO
  • Molecular Weight 298.90
  • Synonym(s) 3-Bromo-4-iodophenol 97
  • SMILES OC1=CC=C(C(Br)=C1)I

Description

3-Bromo-4-iodophenol features a phenolic hydroxyl group flanked by bromo and iodo substituents at adjacent positions, enabling selective functionalization in cross-coupling reactions. The electron-withdrawing halogens enhance reactivity while maintaining stability under standard conditions, facilitating incorporation into complex molecular architectures.

Application

3-Bromo-4-iodophenol serves as a versatile diaryl building block for palladium-catalyzed cross-coupling reactions, enabling efficient construction of biaryl scaffolds. Its orthogonal halogen reactivity—bromine readily participates in Suzuki, Stille, and Negishi couplings while iodine supports rapid Buchwald-Hartwig amination—facilitates sequential functionalization. The phenolic hydroxyl group offers additional handle for derivatization or protection, enhancing synthetic flexibility. Bench-stable and amenable to purification by recrystallization, it functions reliably in iterative synthesis workflows.

Synthesis

  • Route1
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      1428963-74-9
    • ~%
    • In-stock
      3-Bromo-4-iodophenol|CS-0098632
      1037298-05-7

    References

    • Noji, Toshiharu; Fujiwara, Hideto; Okano, Kentaro; Tokuyama, Hidetoshi Organic Letters, 2013 , vol. 15, # 8 p. 1946 - 1949
  • Route2
    • null|null
      100-02-7
    • ~%
    • In-stock
      3-Bromo-4-iodophenol|CS-0098632
      1037298-05-7

    References

    • Noji, Toshiharu; Fujiwara, Hideto; Okano, Kentaro; Tokuyama, Hidetoshi Organic Letters, 2013 , vol. 15, # 8 p. 1946 - 1949
  • Route3
    • null|null
      20455-07-6
    • ~%
    • In-stock
      3-Bromo-4-iodophenol|CS-0098632
      1037298-05-7

    References

    • Noji, Toshiharu; Fujiwara, Hideto; Okano, Kentaro; Tokuyama, Hidetoshi Organic Letters, 2013 , vol. 15, # 8 p. 1946 - 1949

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05,GHS07
Signal Word : Danger
UN#: 1759
Class : 8
Packing Group : Ⅲ
Hazard Statements : H302-H315-H318-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   20.23
  • LogP   2.7593
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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