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CS-W001157 4
Total: USD 88.00

5-Fluoro-2-methylpyridine

  • CAS No. 31181-53-0

  • Cat. No. CS-W006280
  • Purity≥96%
  • MDL No.MFCD03095271

*For research and further manufacturing use only, not for direct human use.

5-Fluoro-2-methylpyridine|CS-W006280

Structure of 31181-53-0

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General Information

  • CAS No. 31181-53-0
  • Cat. No. CS-W006280
  • Purity ≥96%
  • MDL No. MFCD03095271
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₆FN
  • Molecular Weight None
  • Synonym(s) 5-Fluoro-2-methyl pyridine
  • SMILES CC1=NC=C(F)C=C1

Description

5-Fluoro-2-methylpyridine serves as a critical building block in medicinal chemistry, offering a unique combination of electron-deficient heterocyclic character and steric control. This bench-stable pyridine derivative integrates readily into pharmaceutical scaffolds, where the fluorine and methyl groups enable tailored electronic and metabolic profiles.

Application

5-Fluoro-2-methylpyridine serves as a versatile building block in medicinal chemistry, enabling direct functionalization at the 3-position via palladium-catalyzed cross-coupling. Its electron-withdrawing fluorine and activating methyl group enhance regioselectivity in electrophilic substitution and facilitate C–H activation processes. The compound exhibits excellent bench stability and compatibility with diverse reaction conditions, making it well-suited for constructing bioactive heterocycles and API intermediates.

Synthesis

  • Route1
    • null|null
      80287-53-2
    • ~53%
    • In-stock
      5-Fluoro-2-methylpyridine|CS-W006280
      31181-53-0

    References

    • F2G LTD Patent: WO2008/62182 A1, 2008 ; Location in patent: Page/Page column 161 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   12.89
  • LogP   1.52912
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

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