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tert-Butyl N-({3-azabicyclo[3.1.0]hexan-1-yl}methyl)carbamate

  • CAS No. 134574-96-2

  • Cat. No. CS-0000132
  • Purity≥98%
  • MDL No.MFCD11035741

*For research and further manufacturing use only, not for direct human use.

tert-Butyl N-({3-azabicyclo[3.1.0]hexan-1-yl}methyl)carbamate|CS-0000132

Structure of 134574-96-2

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General Information

  • CAS No. 134574-96-2
  • Cat. No. CS-0000132
  • Purity ≥98%
  • MDL No. MFCD11035741
  • Storage RT, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₂₀N₂O₂
  • Molecular Weight 212.29
  • Synonym(s) tert-Butyl (3-azabicyclo[3.1.0]hexan-1-ylmethyl)carbamate
  • SMILES O=C(OC(C)(C)C)NCC12CC1CNC2

Description

tert-Butyl N-({3-azabicyclo[3.1.0]hexan-1-yl}methyl)carbamate features a rigid, conformationally constrained bicyclic amine scaffold that enables precise spatial control in synthetic applications. The carbamate group offers stable protection under standard conditions, facilitating selective deprotection and integration into complex molecular architectures. This compound serves as a key building block for bioactive molecule synthesis.

Application

tert-Butyl N-({3-azabicyclo[3.1.0]hexan-1-yl}methyl)carbamate serves as a robust, bench-stable amine protecting group for nitrogen-functionalized bicyclic scaffolds. It facilitates selective deprotection under mild acidic conditions, enabling straightforward access to the parent amine for downstream coupling or functionalization. The carbamate moiety exhibits excellent compatibility with diverse reaction conditions, supporting its use in iterative synthesis of complex heterocyclic systems and medicinal chemistry campaigns.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   50.36
  • LogP   1.1206
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   2

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