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CS-W001157 4
Total: USD 88.00

1-(4-Methoxybenzyl)-1H-pyrazole-4-carboxylic acid

  • CAS No. 1105039-93-7

  • Cat. No. CS-0150392
  • Molecule weight232.24
  • Purity≥98%
  • MDL No.MFCD08456928

*For research and further manufacturing use only, not for direct human use.

1-(4-Methoxybenzyl)-1H-pyrazole-4-carboxylic acid|CS-0150392

Structure of 1105039-93-7

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General Information

  • CAS No. 1105039-93-7
  • Cat. No. CS-0150392
  • Purity ≥98%
  • MDL No. MFCD08456928
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₁₂N₂O₃
  • Molecular Weight 232.24
  • Synonym(s) Piraxostat Impurity 36
  • SMILES COC1=CC=C(C=C1)CN2C=C(C=N2)C(=O)O

Description

This pyrazole derivative features a methoxybenzyl group that enhances solubility and stability in organic media. The carboxylic acid moiety enables direct conjugation or derivatization in synthetic routes. Designed for use in medicinal chemistry, it integrates readily into bioactive scaffolds requiring polar, electron-rich functionalities.

Application

1-(4-Methoxybenzyl)-1H-pyrazole-4-carboxylic acid serves as a versatile building block for the synthesis of bioactive heterocycles, enabling efficient functionalization at the pyrazole core. The carboxylic acid group facilitates direct coupling reactions, while the 4-methoxybenzyl moiety provides bench stability and orthogonal protection potential. This compound exhibits excellent functional group tolerance and is compatible with standard amide bond formation, Suzuki coupling, and reductive deprotection protocols, making it ideal for medicinal chemistry campaigns targeting kinase inhibitors and CNS-active scaffolds.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   64.35
  • LogP   1.6382
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   4

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