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CS-W001157 4
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8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one

  • CAS No. 31251-41-9

  • Cat. No. CS-0022883
  • Purity≥98%
  • MDL No.MFCD00800222

*For research and further manufacturing use only, not for direct human use.

8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one|CS-0022883

Structure of 31251-41-9

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General Information

  • CAS No. 31251-41-9
  • Cat. No. CS-0022883
  • Purity ≥98%
  • MDL No. MFCD00800222
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₄H₁₀ClNO
  • Molecular Weight 243.69
  • Synonym(s) None
  • SMILES O=C1C2=CC=C(Cl)C=C2CCC3=CC=CN=C31

Description

08:0 DG (1,2-dioctanoyl-sn-glycerol), also called as di-C8, is a cell-permeable and a short-chain diacyl glycerol.08:0 DG may be used as a component of phosphatidylinositol 3-phosphate (PI3P) liposomes for vacuolar morphogenesis protein 7 (Vam7-6A) binding studies. It has been used in T-cell lymphoma invasion and metastasisinducing protein 1 (TIAM1) transfection studies.

Application

8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one serves as a versatile heterocyclic building block for medicinal chemistry applications. Its fused tricyclic structure provides rigidity and defined spatial orientation, while the chloro substituent enables further functionalization via palladium-catalyzed cross-coupling. The ketone moiety offers direct access to diverse downstream transformations, including reductive amination and nucleophilic addition, facilitating rapid scaffold diversification in target-oriented synthesis.

Synthesis

  • Route1

    References

    • ALANTOS PHARMACEUTICALS, INC. Patent: WO2006/116157 A2, 2006 ; Location in patent: Page/Page column 56-57 ; WO 2006/116157 A2
  • Route2
    • null|null
      251353-79-4
    • ~88%
    • In-stock
      8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one|CS-0022883
      31251-41-9

    References

    • Poirier, Marc; Chen, Frank; Bernard, Charles; Wong, Yee-Shing; Wu, George G. Organic Letters, 2001 , vol. 3, # 23 p. 3795 - 3798
  • Route3
    • null|null
      255861-49-5
    • ~%
    • In-stock
      8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one|CS-0022883
      31251-41-9

    References

    • EP1098882 B1, ; Page 8 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

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Computational Chemistry Data

  • TPSA   29.96
  • LogP   3.0646
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   0

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