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CS-W001157 4
Total: USD 88.00

6,7-Dihydroquinolin-8(5H)-one

  • CAS No. 56826-69-8

  • Cat. No. CS-D1458
  • Purity≥97%
  • MDL No.MFCD03839916

*For research and further manufacturing use only, not for direct human use.

6,7-Dihydroquinolin-8(5H)-one|CS-D1458

Structure of 56826-69-8

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General Information

  • CAS No. 56826-69-8
  • Cat. No. CS-D1458
  • Purity ≥97%
  • MDL No. MFCD03839916
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₉NO
  • Molecular Weight 147.17
  • Synonym(s) None
  • SMILES O=C1CCCC2=C1N=CC=C2

Description

6,7-Dihydroquinolin-8(5H)-one features a saturated quinoline core with a lactam functionality at the 8-position, offering a rigid, electron-rich scaffold ideal for medicinal chemistry. This bench-stable heterocycle integrates readily into kinase inhibitors and CNS-targeted compounds, where its polarity and hydrogen-bonding capacity enhance target engagement and metabolic stability.

Synthesis

  • Route1
    • 8-(Phenylmethylidene)-5,6,7,8-tetrahydroquinoline|CS-0233666
      28707-60-0
    • ~89%
    • In-stock
      6,7-Dihydroquinolin-8(5H)-one|CS-D1458
      56826-69-8

    References

    • Boggs, Sharon; Elitzin, Vassil I.; Gudmundsson, Kristjan; Martin, Michael T.; Sharp, Matthew J. Organic Process Research and Development, 2009 , vol. 13, # 4 p. 781 - 785
  • Route2

    References

    • Bridger, Gary; Skerlj, Renato; Kaller, Ai; Harwig, Curtis; Bogucki, David; Wilson, Trevor R.; Crawford, Jason; McEachern, Ernest J.; Atsma, Bem; Nan, Siqiao; Zhou, Yuanxi; Schols, Dominique; Smith, Christopher Dennis; Di Fluri, Maria Rosaria Patent: US2003/220341 A1, 2003 ; Location in patent: Page/Page column 9 ; US 20030220341 A1
  • Route3

    References

    • Kelly, T. Ross; Lebedev, Rimma L. Journal of Organic Chemistry, 2002 , vol. 67, # 7 p. 2197 - 2205

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   29.96
  • LogP   1.6006
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   0

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