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CS-W001157 4
Total: USD 88.00

4-Ethynylquinoline

  • CAS No. 62484-52-0

  • Cat. No. CS-0019257
  • Purity≥98%
  • MDL No.MFCD08703535

*For research and further manufacturing use only, not for direct human use.

4-Ethynylquinoline|CS-0019257

Structure of 62484-52-0

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General Information

  • CAS No. 62484-52-0
  • Cat. No. CS-0019257
  • Purity ≥98%
  • MDL No. MFCD08703535
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₇N
  • Molecular Weight 153.18
  • Synonym(s) 4-ETHYNYL-QUINOLINE
  • SMILES C#CC1=CC=NC2=CC=CC=C12

Description

4-Ethynylquinoline serves as a pivotal building block in transition-metal-catalyzed coupling reactions, enabling efficient access to conjugated architectures. The terminal alkyne moiety integrates readily into complex frameworks under standard conditions, while the quinoline scaffold provides enhanced electronic delocalization and stability. This combination facilitates applications in materials science and medicinal chemistry.

Application

4-Ethynylquinoline serves as a versatile building block in transition-metal-catalyzed coupling reactions, enabling efficient access to conjugated systems and heterocyclic architectures. Its terminal alkyne functionality exhibits excellent stability under standard handling conditions and tolerates a range of functional groups, facilitating straightforward purification and integration into complex molecular frameworks.

Synthesis

  • Route1

    References

    • Synthesis, , # 4 p. 312 - 314
  • Route2
    • 4-((Trimethylsilyl)Ethynyl)quinoline|CS-0768190
      86521-09-7
    • ~73%
    • In-stock
      4-Ethynylquinoline|CS-0019257
      62484-52-0

    References

    • Synthesis, , # 4 p. 312 - 314
  • Route3
    • 2-Methyl-4-quinolin-4-ylbut-3-yn-2-ol|CS-0768185
      831235-65-5
    • ~75%
    • In-stock
      4-Ethynylquinoline|CS-0019257
      62484-52-0

    References

    • Tetrahedron, , vol. 61, # 38 p. 9042 - 9051

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   12.89
  • LogP   2.2161
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

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