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CS-W001157 4
Total: USD 88.00

5-Methylquinoline

  • CAS No. 7661-55-4

  • Cat. No. CS-W019214
  • Purity≥97%
  • MDL No.MFCD01685457

*For research and further manufacturing use only, not for direct human use.

5-Methylquinoline|CS-W019214

Structure of 7661-55-4

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General Information

  • CAS No. 7661-55-4
  • Cat. No. CS-W019214
  • Purity ≥97%
  • MDL No. MFCD01685457
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₉N
  • Molecular Weight 143.19
  • Synonym(s) 5-20-07-00399 (Beilstein Handbook Reference)
  • SMILES CC1=CC=CC2=C1C=CC=N2

Description

5-Methylquinoline is a heterocyclic compound featuring a methyl group at the 5-position of the quinoline core. This substitution enhances electron density at the aromatic system, improving reactivity in electrophilic functionalization. The molecule exhibits good solubility in organic solvents and demonstrates stability under standard bench conditions, making it suitable for use in synthetic transformations and as a ligand in transition metal catalysis.

Application

5-Methylquinoline serves as a versatile heterocyclic building block in medicinal chemistry and catalysis, offering a robust scaffold for drug discovery and ligand design. Its methyl substituent enhances metabolic stability and modulates electronic properties, enabling efficient transition-metal-catalyzed cross-coupling reactions. The compound exhibits excellent bench stability, facilitates straightforward purification, and functions effectively in C–H functionalization and Pd-catalyzed transformations.

Synthesis

  • Route1
    • null|null
      99-08-1
    • In-stock
      3-Aminopropan-1-ol|CS-W020089
      156-87-6
    • ~%
    • null|null
      612-60-2
    • In-stock
      5-Methylquinoline|CS-W019214
      7661-55-4

    References

    • Journal of Heterocyclic Chemistry, , vol. 39, # 2 p. 291 - 294
  • Route2
    • In-stock
      Glycerol|CS-6964
      56-81-5
    • null|null
      108-44-1
    • ~26%
    • null|null
      612-60-2
    • In-stock
      5-Methylquinoline|CS-W019214
      7661-55-4

    References

    • Organic Letters, , vol. 16, # 1 p. 142 - 145
  • Route3
    • null|null
      108-44-1
    • In-stock
      3-Aminopropan-1-ol|CS-W020089
      156-87-6
    • ~%
    • null|null
      612-60-2
    • In-stock
      5-Methylquinoline|CS-W019214
      7661-55-4

    References

    • Journal of Heterocyclic Chemistry, , vol. 36, # 5 p. 1175 - 1178

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS06,GHS08,GHS09
Signal Word : Danger
UN#: 2810
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301-H312-H315-H319-H341-H350-H411
Precautionary Statements : P264-P273-P280

Quality Control

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Computational Chemistry Data

  • TPSA   12.89
  • LogP   2.54322
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

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