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CS-W001157 4
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6-Fluoronaphthalen-2-ol

  • CAS No. 13101-83-2

  • Cat. No. CS-0102645
  • Molecule weight162.16
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

6-Fluoronaphthalen-2-ol|CS-0102645

Structure of 13101-83-2

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General Information

  • CAS No. 13101-83-2
  • Cat. No. CS-0102645
  • Purity ≥97%
  • MDL No. None
  • Storage RT, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₇FO
  • Molecular Weight 162.16
  • Synonym(s) 2-Naphthalenol,6-fluoro
  • SMILES OC1=CC=C2C=C(F)C=CC2=C1

Description

6-Fluoronaphthalen-2-ol features a fluorine atom at the 6-position of the naphthalene core, flanked by a phenolic hydroxyl group at the 2-position. This combination imparts enhanced electron-withdrawing character and improved solubility in polar solvents. The molecule exhibits bench-stable behavior under standard conditions and serves as a key building block for bioactive heterocycles and functional materials.

Application

6-Fluoronaphthalen-2-ol serves as a versatile building block in medicinal chemistry, enabling direct functionalization at the 2-position via nucleophilic substitution due to activation by the adjacent hydroxyl group. Its bench-stable nature and compatibility with common coupling reactions facilitate efficient synthesis of naphthalene-based scaffolds. The fluorine substituent enhances metabolic stability and modulates electronic properties, making it valuable for optimizing bioactive compounds.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   20.23
  • LogP   2.6845
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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