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CS-W001157 4
Total: USD 88.00

8-Fluoronaphthalen-2-ol

  • CAS No. 13916-98-8

  • Cat. No. CS-D0205
  • Purity≥98%
  • MDL No.MFCD09037976

*For research and further manufacturing use only, not for direct human use.

8-Fluoronaphthalen-2-ol|CS-D0205

Structure of 13916-98-8

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General Information

  • CAS No. 13916-98-8
  • Cat. No. CS-D0205
  • Purity ≥98%
  • MDL No. MFCD09037976
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₇FO
  • Molecular Weight 162.16
  • Synonym(s) 8-FLUORO-2-NAPHTHOL
  • SMILES OC1=CC=C2C=CC=C(F)C2=C1

Description

8-Fluoronaphthalen-2-ol features a fluorine atom at the 8-position of naphthalene, strategically positioned to modulate electronic properties and enhance metabolic stability. The phenolic hydroxyl group enables direct functionalization or hydrogen bonding interactions in synthetic applications. This bench-stable compound integrates readily into complex molecular architectures requiring precise spatial and electronic control.

Application

8-Fluoronaphthalen-2-ol serves as a versatile building block for the synthesis of fluorinated heterocycles and bioactive molecules. Its ortho-hydroxyl group enables facile metal-catalyzed coupling reactions, while the 8-fluoro substituent provides enhanced electrophilicity for nucleophilic aromatic substitution. The compound exhibits good bench stability and is compatible with standard purification methods, facilitating its use in iterative synthetic sequences for pharmaceutical and agrochemical research.

Synthesis

  • Route1
    • 1-Fluoro-7-methoxynaphthalene|CS-0337515
      13791-03-2
    • ~97%
    • In-stock
      8-Fluoronaphthalen-2-ol|CS-D0205
      13916-98-8

    References

    • Jin, Jian; Morales-Ramos, Angel; Eidam, Patrick; Mecom, John; Li, Yue; Brooks, Carl; Hilfiker, Mark; Zhang, David; Wang, Ning; Shi, Dongchuan; Tseng, Pei-San; Wheless, Karen; Budzik, Brian; Evans, Karen; Jaworski, Jon-Paul; Jugus, Jack; Leon, Lisa; Wu, Charlene; Pullen, Mark; Karamshi, Bhumika; Rao, Parvathi; Ward, Emma; Laping, Nicholas; Evans, Christopher; Leach, Colin; Holt, Dennis; Su, Xin; Morrow, Dwight; Fries, Harvey; Thorneloe, Kevin; Edwards, Richard ACS Medicinal Chemistry Letters, 2010 , vol. 1, # 7 p. 316 - 320
  • Route2

    References

    • Journal of Medicinal Chemistry, , vol. 48, # 12 p. 3953 - 3979
  • Route3
    • N-(7-methoxynaphthalen-1-yl)acetamide|CS-0555373
      93189-18-5
    • ~%
    • In-stock
      8-Fluoronaphthalen-2-ol|CS-D0205
      13916-98-8

    References

    • Journal of Medicinal Chemistry, , vol. 48, # 12 p. 3953 - 3979

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   20.23
  • LogP   2.6845
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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