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CS-W001157 4
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4-Fluoronaphthalen-1-ol

  • CAS No. 315-53-7

  • Cat. No. CS-0040737
  • Purity≥95%
  • MDL No.MFCD10699695

*For research and further manufacturing use only, not for direct human use.

4-Fluoronaphthalen-1-ol|CS-0040737

Structure of 315-53-7

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General Information

  • CAS No. 315-53-7
  • Cat. No. CS-0040737
  • Purity ≥95%
  • MDL No. MFCD10699695
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₇FO
  • Molecular Weight 162.16
  • Synonym(s) 4-Fluoro-1-naphthol.
  • SMILES OC1=C2C=CC=CC2=C(F)C=C1

Description

4-Fluoronaphthalen-1-ol offers a strategic fusion of aromatic rigidity and polar functionality, enabling direct incorporation into bioactive scaffolds. The para-fluorine enhances metabolic stability while the phenolic hydroxyl facilitates hydrogen bonding and downstream derivatization. This bench-stable compound serves as a key intermediate in pharmaceutical and agrochemical synthesis.

Application

4-Fluoronaphthalen-1-ol serves as a versatile building block for the synthesis of functionalized naphthalene scaffolds, enabling direct electrophilic substitution and palladium-catalyzed coupling reactions. The ortho-fluoro substitution facilitates selective C–H activation, while the phenolic hydroxyl group offers sites for derivatization or protection. Its bench-stable crystalline form simplifies handling and purification in synthetic workflows.

Synthesis

  • Route1

    References

    • Journal of Organic Chemistry, , vol. 60, # 20 p. 6592 - 6594
  • Route2
    • null|null
      90990-92-4
    • ~90%
    • In-stock
      4-Fluoronaphthalen-1-ol|CS-0040737
      315-53-7

    References

    • Adejare, Adeboye; Sciberras, Sophie S. Pharmaceutical Research, 1997 , vol. 14, # 4 p. 533 - 536
  • Route3
    • 1-Naphthol Duloxetine Impurity|CS-0213938
      90-15-3
    • ~39%
    • 2-Fluoronaphthalen-1-ol|CS-0564474
      56874-95-4
    • null|null
      97295-09-5
    • In-stock
      4-Fluoronaphthalen-1-ol|CS-0040737
      315-53-7

    References

    • Bulletin of the Chemical Society of Japan, , vol. 68, # 6 p. 1655 - 1660

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   20.23
  • LogP   2.6845
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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