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CS-W001157 4
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7-Fluoronaphthalen-2-ol

  • CAS No. 889884-94-0

  • Cat. No. CS-0197478
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

7-Fluoronaphthalen-2-ol|CS-0197478

Structure of 889884-94-0

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General Information

  • CAS No. 889884-94-0
  • Cat. No. CS-0197478
  • Purity ≥98%
  • MDL No. None
  • Storage RT, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₇FO
  • Molecular Weight 162.16
  • Synonym(s) 2-Fluoro-7-hydroxynaphthalene
  • SMILES OC1=CC=C2C=CC(F)=CC2=C1

Description

7-Fluoronaphthalen-2-ol features a fluorine atom at the 7-position of naphthalene, strategically positioned to modulate electronic properties and enhance metabolic stability. The phenolic hydroxyl group enables direct functionalization or hydrogen bonding interactions in synthetic applications. This dual-functionalized scaffold integrates readily into complex molecular architectures requiring precise electronic tuning and controlled reactivity under standard conditions.

Application

7-Fluoronaphthalen-2-ol serves as a versatile building block for the synthesis of functionalized naphthalene derivatives, enabling direct substitution at the C-2 position via nucleophilic aromatic substitution. Its fluorine atom enhances electrophilicity at the adjacent ring position, facilitating coupling reactions with amines and thiols under mild conditions. The phenolic hydroxyl group provides a handle for derivatization, including etherification and esterification, while maintaining stability during standard synthetic manipulations. This compound functions reliably in medicinal chemistry and materials science applications requiring ortho-substituted naphthalene scaffolds.

Synthesis

  • Route1
    • null|null
      889884-93-9
    • ~87%
    • In-stock
      7-Fluoronaphthalen-2-ol|CS-0197478
      889884-94-0

    References

    • SOLVAY PHARMACEUTICALS B.V. Patent: US2006/122189 A1, 2006 ; Location in patent: Page/Page column 25 ; US 20060122189 A1
  • Route2
    • 7-Fluoro-2-tetralone|CS-B0111
      29419-15-6
    • ~%
    • In-stock
      7-Fluoronaphthalen-2-ol|CS-0197478
      889884-94-0

    References

    • Adcock,W. et al. Australian Journal of Chemistry, 1970 , vol. 23, p. 1921 - 1937
  • Route3

    References

    • Adcock,W. et al. Australian Journal of Chemistry, 1970 , vol. 23, p. 1921 - 1937

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   20.23
  • LogP   2.6845
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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