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CS-W001157 4
Total: USD 88.00

1-(2-Chloroethyl)-4-methylpiperazine hydrochloride

  • CAS No. 126055-32-1

  • Cat. No. CS-W006314
  • Purity≥95%
  • MDL No.MFCD12031872

*For research and further manufacturing use only, not for direct human use.

1-(2-Chloroethyl)-4-methylpiperazine hydrochloride|CS-W006314

Structure of 126055-32-1

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General Information

  • CAS No. 126055-32-1
  • Cat. No. CS-W006314
  • Purity ≥95%
  • MDL No. MFCD12031872
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₁₆Cl₂N₂
  • Molecular Weight 199.12
  • Synonym(s) None
  • SMILES Cl.CN1CCN(CCCl)CC1

Description

This hydrochloride salt features a 1-(2-chloroethyl)-4-methylpiperazine scaffold with enhanced solubility and stability under standard conditions. The chloroethyl moiety enables efficient alkylation reactions, while the protonated piperazine nitrogen facilitates downstream conjugation. Ideal for synthetic intermediates in medicinal chemistry.

Application

1-(2-Chloroethyl)-4-methylpiperazine hydrochloride serves as a versatile bifunctional electrophile in medicinal chemistry, enabling efficient introduction of piperazine-based side chains into target molecules. The chloroethyl group facilitates nucleophilic substitution under mild conditions, while the protonated piperazine nitrogen enhances solubility and reactivity. This compound demonstrates excellent bench stability and compatibility with common protecting group strategies, making it a reliable building block for API synthesis and library diversification.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   6.48
  • LogP   0.8944
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   2

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