N,N-Dimethylpiperazine-1-carboxamide

Name: N,N-Dimethylpiperazine-1-carboxamide
Brand: ChemScene
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CAS No. 41340-78-7
Cat. No. CS-0151344
Purity≥95%
MDL No.MFCD01050443

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
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N,N-Dimethylpiperazine-1-carboxamide|CS-0151344

Structure of 41340-78-7

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General Information

CAS No. 41340-78-7
Cat. No. CS-0151344
Purity ≥95%
MDL No. MFCD01050443
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₇H₁₅N₃O
Molecular Weight 157.21
Synonym(s) PIPERAZINE-1-CARBOXYLIC ACID DIMETHYLAMIDE
SMILES CN(C)C(=O)N1CCNCC1

Description

N,N-Dimethylpiperazine-1-carboxamide features a sterically hindered piperazine core with dual dimethylamino groups, enhancing solubility and metabolic stability. The carboxamide functionality provides a robust hydrogen-bonding motif for target engagement. This compound serves as a key scaffold in medicinal chemistry, integrating well into bioactive molecules requiring balanced lipophilicity and polarity.

Application

N,N-Dimethylpiperazine-1-carboxamide serves as a versatile amide building block in medicinal chemistry, offering enhanced solubility and metabolic stability compared to simpler alkyl amides. Its piperazine core provides a rigid, polar scaffold ideal for modulating pharmacokinetic properties. The dimethylamino groups enhance basicity and hydrogen-bonding capacity, facilitating interactions with biological targets. This compound functions effectively in coupling reactions and acts as a key intermediate in the synthesis of heterocyclic APIs and kinase inhibitors.

Synthesis

Route1
- 110-85-0
- 79-44-7
- ~13%
- In-stock
  
  41340-78-7
References
- Schering Corporation Patent: US2004/106794 A1, 2004 ; Location in patent: Page 163 ; US 20040106794 A1
Route2
- In-stock
  
  215453-81-9
- ~%
- In-stock
  
  41340-78-7
References
- Wu, Yulin; Kuntz, Judith D.; Carpenter, Andrew J.; Fang, Jing; Sauls, Howard R.; Gomez, Daniel J.; Ammala, Carina; Xu, Yun; Hart, Shane; Tadepalli, Sarva Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 8 p. 2577 - 2581

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS05
Signal Word : Danger	UN#: 1759
Class : 8	Packing Group : Ⅲ
Hazard Statements : H314
Precautionary Statements : P260-P264-P280-P301+P330+P331-P304+P340-P363-P405-P501

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Computational Chemistry Data

TPSA 35.58
LogP -0.4268
H_Acceptors 2
H_Donors 1
Rotatable_Bonds 0

Other Classifications

Building Blocks Skeleton Aliphatic heterocycle compounds Piperazine compounds

Key Words

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N,N-Dimethylpiperazine-1-carboxamide

CAS No. 41340-78-7

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