2-Bromo-6-chloronicotinonitrile

Name: 2-Bromo-6-chloronicotinonitrile
Brand: ChemScene
Availability: InStock
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CAS No. 1256833-80-3
Cat. No. CS-0186588
Purity≥98%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
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2-Bromo-6-chloronicotinonitrile|CS-0186588

Structure of 1256833-80-3

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Description

2-Bromo-6-chloronicotinonitrile features a highly functionalized pyridine core bearing bromo, chloro, and nitrile groups at the 2-, 6-, and 3-positions, respectively. This electron-deficient heterocycle serves as a key building block in agrochemical and pharmaceutical synthesis, enabling efficient coupling reactions under standard conditions. The strategic placement of halogens facilitates selective cross-coupling transformations, while the nitrile group offers additional anchoring points for derivatization.

Application

2-Bromo-6-chloronicotinonitrile serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its complementary halogen reactivity. The nitrile group provides a handle for further functionalization, while the ortho-bromo and meta-chloro substituents offer orthogonal reactivity for sequential transformations. Its bench-stable crystalline form facilitates handling and purification, making it well-suited for iterative synthesis of heterocyclic scaffolds and API intermediates.

General Information

CAS No. 1256833-80-3
Cat. No. CS-0186588
Purity ≥98%
MDL No. None
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₂BrClN₂
Molecular Weight 217.45
Synonym(s) 2-bromo-6-chloropyridine-3-carbonitrile
SMILES N#CC1=C(Br)N=C(Cl)C=C1

Computational Chemistry Data

TPSA 36.68
LogP 2.36918
H_Acceptors 2
H_Donors 0
Rotatable_Bonds 0

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Other Classifications

Building Blocks Functional Group Cyanide/Nitrile

Building Blocks Functional Group Bromide

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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2-Bromo-6-chloronicotinonitrile

CAS No. 1256833-80-3

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