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tert-Butyl (4-(chlorosulfonyl)phenyl)carbamate

  • CAS No. 269747-25-3

  • Cat. No. CS-0103564
  • Purity≥96%
  • MDL No.MFCD10697736

*For research and further manufacturing use only, not for direct human use.

tert-Butyl (4-(chlorosulfonyl)phenyl)carbamate|CS-0103564

Structure of 269747-25-3

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General Information

  • CAS No. 269747-25-3
  • Cat. No. CS-0103564
  • Purity ≥96%
  • MDL No. MFCD10697736
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₁₄ClNO₄S
  • Molecular Weight 291.75
  • Synonym(s) tert-butyl4-(chlorosulfonyl)phenylcarbamate
  • SMILES O=C(OC(C)(C)C)NC1=CC=C(S(=O)(Cl)=O)C=C1

Description

tert-Butyl (4-(chlorosulfonyl)phenyl)carbamate features a robust tert-butyl carbamate protecting group paired with a reactive chlorosulfonyl moiety. This combination enables selective derivatization of amines under mild conditions, facilitating the construction of sulfonamide-linked architectures in synthetic and medicinal chemistry workflows.

Application

tert-Butyl (4-(chlorosulfonyl)phenyl)carbamate serves as a versatile building block for sulfonamide synthesis, enabling direct introduction of a para-chlorosulfonylaryl group under mild conditions. Its tert-butyl carbamate moiety provides stability and facilitates convenient deprotection, while the chlorosulfonyl group offers high reactivity in nucleophilic substitution reactions. This compound functions effectively in the construction of biologically relevant heterocycles and API intermediates, offering excellent functional group tolerance and ease of purification in standard synthetic workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 3261
Class : 8
Packing Group : Ⅲ
Hazard Statements : H314
Precautionary Statements : P260-P264-P280-P301+P330+P331-P304+P340-P363-P405-P501

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Computational Chemistry Data

  • TPSA   72.47
  • LogP   2.9611
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   2

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