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2-Bromo-6-chloronicotinaldehyde

  • CAS No. 1060815-60-2

  • Cat. No. CS-0128602
  • Purity≥97%
  • MDL No.MFCD11844804

*For research and further manufacturing use only, not for direct human use.

2-Bromo-6-chloronicotinaldehyde|CS-0128602

Structure of 1060815-60-2

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General Information

  • CAS No. 1060815-60-2
  • Cat. No. CS-0128602
  • Purity ≥97%
  • MDL No. MFCD11844804
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₃BrClNO
  • Molecular Weight 220.45
  • Synonym(s) 2-bromo-6-chloropyridine-3-carbaldehyde
  • SMILES O=CC1=C(Br)N=C(Cl)C=C1

Description

2-Bromo-6-chloronicotinaldehyde is a halogenated pyridine aldehyde featuring orthogonal reactivity at the aldehyde and halide sites. This electron-deficient heterocycle integrates readily into cross-coupling cascades and serves as a key building block for bioactive scaffolds in medicinal chemistry.

Application

2-Bromo-6-chloronicotinaldehyde serves as a versatile building block in medicinal chemistry, enabling the construction of heterocyclic scaffolds via palladium-catalyzed cross-coupling and nucleophilic substitution reactions. Its ortho-halogenated aldehyde functionality offers high reactivity in C–H functionalization and facilitates efficient derivatization under mild conditions. The compound exhibits good bench stability and is compatible with diverse protecting groups, making it well-suited for iterative synthesis campaigns in API development.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   29.96
  • LogP   2.31
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

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