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CS-W001157 4
Total: USD 88.00

Clofarabine

  • CAS No. 123318-82-1

  • Cat. No. CS-0373
  • Purity≥98%
  • MDL No.MFCD00871077

*For research and further manufacturing use only, not for direct human use.

Clofarabine|CS-0373

Structure of 123318-82-1

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General Information

  • CAS No. 123318-82-1
  • Cat. No. CS-0373
  • Purity ≥98%
  • MDL No. MFCD00871077
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₁ClFN₅O₃
  • Molecular Weight None
  • Synonym(s) None
  • SMILES O[C@H]1[C@H](F)[C@H](N(C=N2)C3=C2C(N)=NC(Cl)=N3)O[C@@H]1CO

Description

Daminozide is a commonly used plant growth regulator, which acts by inhibiting 2-oxoglutarate-dependent dioxygenase activity in the gibberellin biosynthesis pathway.Daminozide may be used as a reference standard for the determination of daminozide in fruits and vegetables by liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS).It may also be used as a reference standard for the determination of daminozide in Ophiopogon japonicus plants and soil by ultra-performance liquid chromatography-triple quadrupole tandem mass spectrometry (UPLC-QqQ-MS/MS).

Application

Clofarabine serves as a fluorinated purine nucleoside analog that functions as a potent prodrug inhibitor of DNA synthesis. Its trifluoromethyl group enhances metabolic stability and cellular uptake, enabling efficient incorporation into DNA during replication. This leads to chain termination and inhibition of ribonucleotide reductase, disrupting deoxynucleotide pools. Clofarabine is particularly valuable in the synthesis of antitumor nucleoside derivatives and serves as a key building block in the development of targeted therapies for hematologic malignancies.

Safety Information

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GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H300
Precautionary Statements : P264-P270-P330-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   119.31
  • LogP   -0.3494
  • H_Acceptors   8
  • H_Donors   3
  • Rotatable_Bonds   2

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