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CS-W001157 4
Total: USD 88.00

4,6-Dimethoxypyrimidin-5-amine

  • CAS No. 15846-15-8

  • Cat. No. CS-0097886
  • Purity≥98%
  • MDL No.MFCD00194013

*For research and further manufacturing use only, not for direct human use.

4,6-Dimethoxypyrimidin-5-amine|CS-0097886

Structure of 15846-15-8

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General Information

  • CAS No. 15846-15-8
  • Cat. No. CS-0097886
  • Purity ≥98%
  • MDL No. MFCD00194013
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₉N₃O₂
  • Molecular Weight 155.15
  • Synonym(s) 5-Amino-4,6-dimethoxypyrimidine
  • SMILES NC1=C(N=CN=C1OC)OC

Description

4,6-Dimethoxypyrimidin-5-amine features a pyrimidine core bearing two methoxy groups and a primary amine at the 5-position, enabling efficient coupling in heterocyclic synthesis. The electron-donating methoxy substituents enhance nucleophilicity at the amine site, while the scaffold exhibits stability under standard reaction conditions. This compound serves as a key intermediate in medicinal chemistry and agrochemical development.

Application

4,6-Dimethoxypyrimidin-5-amine serves as a versatile building block in medicinal chemistry, enabling efficient construction of pyrimidine-based scaffolds. Its ortho-dimethoxy substitution pattern enhances stability and facilitates nucleophilic displacement reactions. The amine functionality provides a direct handle for coupling reactions, including amidation and urea formation, supporting rapid diversification in target molecule synthesis. Well-suited for bench-scale applications, it exhibits good solubility and purification compatibility.

Synthesis

  • Route1
    • 4,6-Dimethoxy-5-nitropyrimidine|CS-0150620
      15846-14-7
    • ~50%
    • In-stock
      4,6-Dimethoxypyrimidin-5-amine|CS-0097886
      15846-15-8

    References

    • Nemeryuk, Michal P.; Sedov, Andrej L.; Safonova, Tamara S.; Cerny, Antonin; Krepelka, Jiri Collection of Czechoslovak Chemical Communications, 1986 , vol. 51, # 1 p. 215 - 233

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   70.26
  • LogP   0.076
  • H_Acceptors   5
  • H_Donors   1
  • Rotatable_Bonds   2

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