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CS-W001157 4
Total: USD 88.00

1H-Indazol-3-amine

  • CAS No. 874-05-5

  • Cat. No. CS-W002482
  • Purity≥98%
  • MDL No.MFCD00182045

*For research and further manufacturing use only, not for direct human use.

1H-Indazol-3-amine|CS-W002482

Structure of 874-05-5

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General Information

  • CAS No. 874-05-5
  • Cat. No. CS-W002482
  • Purity ≥98%
  • MDL No. MFCD00182045
  • Storage RT, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₇N₃
  • Molecular Weight None
  • Synonym(s) 1H-Indazole,3-amino- (6CI,7CI,8CI); 1H-Indazol-3-amine
  • SMILES NC1=NNC2=C1C=CC=C2

Description

1H-Indazol-3-amine serves as a key heterocyclic scaffold in medicinal chemistry, featuring a nitrogen-rich core that enables robust hydrogen bonding and π-stacking interactions. This bench-stable compound integrates readily into kinase inhibitor architectures and bioactive molecule frameworks, offering high solubility in polar solvents and compatibility with diverse coupling reactions under standard conditions.

Application

1H-Indazol-3-amine serves as a versatile building block in medicinal chemistry, enabling the construction of diverse heterocyclic scaffolds through straightforward functionalization at the amine and C3 positions. Its stability under standard reaction conditions and compatibility with common coupling protocols facilitate efficient synthesis of bioactive molecules. The scaffold is widely employed in kinase inhibitor development and other targeted therapeutic agents.

Synthesis

  • Route1
    • null|null
      394-47-8
    • ~44%
    • In-stock
      1H-Indazol-3-amine|CS-W002482
      874-05-5

    References

    • AVEXA LIMITED Patent: WO2008/77188 A1, 2008 ; Location in patent: Page/Page column 127-128 ;
  • Route2
    • 3-(2-Aminophenyl)-1,2,4-oxadiazol-5(2H)-one|CS-0540477
      166118-78-1
    • ~66%
    • In-stock
      1H-Indazol-3-amine|CS-W002482
      874-05-5

    References

    • BIOFOCUS DISCOVERY LIMITED Patent: WO2005/56532 A1, 2005 ; Location in patent: Page/Page column 22-23 ; WO 2005/056532 A1
  • Route3
    • null|null
      394-47-8
    • null|null
      7727-37-9
    • ~9%
    • In-stock
      1H-Indazol-3-amine|CS-W002482
      874-05-5

    References

    • BRISTOL-MYERS SQUIBB COMPANY Patent: WO2008/157162 A1, 2008 ; Location in patent: Page/Page column 208 ; WO 2008/157162 A1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H301-H315-H319-H335
Precautionary Statements : P260-P264-P270-P271-P280-P301+P310-P302+P352-P304+P340-P305+P351+P338-P312-P330-P332+P313-P337+P313-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   54.7
  • LogP   1.1451
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   0

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